产品
编 号：F755772
分子式：C29H25ClFN3O3
分子量：517.98
分子式：C29H25ClFN3O3
分子量：517.98
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CAS No: 2765535-21-3
产品详情
生物活性：
PD-1/PD-L1-IN-32 (compound A56) is a potent PD-1/PD-L1 inhibitor (IC50=2.4 nM), with anticancer activity. PD-1/PD-L1-IN-32 significantly inhibits tumor growth in hPD-L1 MC38 humanized mouse model, without obvious toxicity against mouse normal ability.
体内研究：
PD-1/PD-L1-IN-32 (compound A56) 在 SD 大鼠中的药代动力学分析RouteDose (mg/kg)AUC(0-t) (μg/L·h)AUC(0-∞) (μg/L·h)Cmax (μg/L)Tmax (h)t1/2 (h)V1 (L/kg)CL (L/h/kg)F (%)
iv811487.4613353.196227.500.080.991.090.60
ig4063579.0865527.7521504.901.751.721.800.62114.09
ip109729.8410504.114156.540.882.432.941.21
PD-1/PD-L1-IN-32 (compound A56) is a potent PD-1/PD-L1 inhibitor (IC50=2.4 nM), with anticancer activity. PD-1/PD-L1-IN-32 significantly inhibits tumor growth in hPD-L1 MC38 humanized mouse model, without obvious toxicity against mouse normal ability.
体内研究：
PD-1/PD-L1-IN-32 (compound A56) 在 SD 大鼠中的药代动力学分析RouteDose (mg/kg)AUC(0-t) (μg/L·h)AUC(0-∞) (μg/L·h)Cmax (μg/L)Tmax (h)t1/2 (h)V1 (L/kg)CL (L/h/kg)F (%)
iv811487.4613353.196227.500.080.991.090.60
ig4063579.0865527.7521504.901.751.721.800.62114.09
ip109729.8410504.114156.540.882.432.941.21
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