产品
编 号：F755763
分子式：C30H32FN5O2
分子量：513.61
分子式：C30H32FN5O2
分子量：513.61
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规格
价格
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结构图
CAS No: 2765251-12-3
产品详情
生物活性：
ZLWH-23 is a selective AChE inhibitor (IC50=0.27 μM) with GSK-3β inhibitory property (IC50=6.78 μM). ZLWH-23 possesses selectivity for AChE over BChE (IC50=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease.
体内研究：
ZLWH-23 displays efficient reduction against tau hyperphosphorylation on Ser-396 site in Tau (P301L) 293T cell model.
体外研究：
ZLWH-23 exhibits good selectivity for GSK-3β over multi-kinases and very low cytotoxicity towards SH-SY5Y, HEK-293T, HL-7702, and HepG2 cell lines.
ZLWH-23 is a selective AChE inhibitor (IC50=0.27 μM) with GSK-3β inhibitory property (IC50=6.78 μM). ZLWH-23 possesses selectivity for AChE over BChE (IC50=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease.
体内研究：
ZLWH-23 displays efficient reduction against tau hyperphosphorylation on Ser-396 site in Tau (P301L) 293T cell model.
体外研究：
ZLWH-23 exhibits good selectivity for GSK-3β over multi-kinases and very low cytotoxicity towards SH-SY5Y, HEK-293T, HL-7702, and HepG2 cell lines.
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