产品
编 号：F755747
分子式：C27H30FN9O
分子量：515.59
分子式：C27H30FN9O
分子量：515.59
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CAS No: 2764891-88-3
产品详情
生物活性：
RET-IN-11 is a potent and selective RET inhibitor with IC50s of 6.20 nM, 18.68 nM for RET and RETV804M, respectively. RET-IN-11 shows anti-proliferation and migration activity in CCDC6-RET-driven LC-2/ad cells. RET-IN-11 induces cell apoptosis.
体外研究：
RET-IN-11 (compound 20)(72 h) shows inhibition activity with an IC50 of 18.68 nM for RETV804M, and shows anti-proliferation activities in CCDC6-RET-driven LC-2/ad cells.RET-IN-11 (0-200 000 nM) shows selectivity with IC50s of 6.20, 96.38, 87.57, 1421.75, >200 000, 100.17, 112.95 nM for RET, Aurora A, CSF-1R, MAP4K4, NEK2, TRKA, FLT3, respectively.RET-IN-11 (500, 1000 nM) induces cell apoptosis in LC-2/ad Cells.RET-IN-11 (1, 2 μM; 48 h) inhibits the migration with the wound healing percentages of 43% and 27% at 1 μM and 2 μM.
RET-IN-11 is a potent and selective RET inhibitor with IC50s of 6.20 nM, 18.68 nM for RET and RETV804M, respectively. RET-IN-11 shows anti-proliferation and migration activity in CCDC6-RET-driven LC-2/ad cells. RET-IN-11 induces cell apoptosis.
体外研究：
RET-IN-11 (compound 20)(72 h) shows inhibition activity with an IC50 of 18.68 nM for RETV804M, and shows anti-proliferation activities in CCDC6-RET-driven LC-2/ad cells.RET-IN-11 (0-200 000 nM) shows selectivity with IC50s of 6.20, 96.38, 87.57, 1421.75, >200 000, 100.17, 112.95 nM for RET, Aurora A, CSF-1R, MAP4K4, NEK2, TRKA, FLT3, respectively.RET-IN-11 (500, 1000 nM) induces cell apoptosis in LC-2/ad Cells.RET-IN-11 (1, 2 μM; 48 h) inhibits the migration with the wound healing percentages of 43% and 27% at 1 μM and 2 μM.
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