产品
编 号：F755731
分子式：C27H32F3N3O3
分子量：503.56
分子式：C27H32F3N3O3
分子量：503.56
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CAS No: 2764772-88-3
产品详情
生物活性：
EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC50s of 20.17 nM, 14.25 nM, respectively. EGFR-IN-46 significantly inhibits the growth of cancer cells. EGFR-IN-46 induces cell apoptosis.
体外研究：
EGFR-IN-46 (compound 6h) (0-100 μM; 24 h) inhibits the growth activity against DLD1, HCT-116 cells with IC50s of 1.79, 3.28 μM, respectively.EGFR-IN-46 (3 μM; 24 h) induces cell apoptosis in DLD1 cells.EGFR-IN-46 exhibits weak TOP1 (Topoisomerase I) poisoning effect (-/+).
EGFR-IN-46 is a potent EGFR and FAK dual inhibitor with IC50s of 20.17 nM, 14.25 nM, respectively. EGFR-IN-46 significantly inhibits the growth of cancer cells. EGFR-IN-46 induces cell apoptosis.
体外研究：
EGFR-IN-46 (compound 6h) (0-100 μM; 24 h) inhibits the growth activity against DLD1, HCT-116 cells with IC50s of 1.79, 3.28 μM, respectively.EGFR-IN-46 (3 μM; 24 h) induces cell apoptosis in DLD1 cells.EGFR-IN-46 exhibits weak TOP1 (Topoisomerase I) poisoning effect (-/+).
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