产品
编 号：F755662
分子式：C18H18FN5O2
分子量：355.37
分子式：C18H18FN5O2
分子量：355.37
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
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询价
结构图
CAS No: 2762422-55-7
产品详情
生物活性：
AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC50 of 0.54 μM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity.
体内研究：
AC1-IN-1 (5.6 mg/kg; i.v.) displays modest, yet statistically significant, antiallodynic effects at 1 h post-treatment compared to the 0 min (allodynic) time point.Animal Model:Male and female C57BL/6N mice (complete Freund’s adjuvant inflammatory pain model)
Dosage:5.6 mg/kg (dissolved in 10% DMSO/10% Cremaphor/80% saline)
Administration:Intravenous injection; 2 hours
Result:Displayed modest, yet statistically significant, antiallodynic effects.
体外研究：
AC1-IN-1 (compound 38; HEK293 cells; 30 μM, 1 hours) shows nontoxic to this human cell line.
AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC50 of 0.54 μM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity.
体内研究：
AC1-IN-1 (5.6 mg/kg; i.v.) displays modest, yet statistically significant, antiallodynic effects at 1 h post-treatment compared to the 0 min (allodynic) time point.Animal Model:Male and female C57BL/6N mice (complete Freund’s adjuvant inflammatory pain model)
Dosage:5.6 mg/kg (dissolved in 10% DMSO/10% Cremaphor/80% saline)
Administration:Intravenous injection; 2 hours
Result:Displayed modest, yet statistically significant, antiallodynic effects.
体外研究：
AC1-IN-1 (compound 38; HEK293 cells; 30 μM, 1 hours) shows nontoxic to this human cell line.
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