产品
编 号：F755646
分子式：C21H18BrF2N3O3
分子量：478.29
分子式：C21H18BrF2N3O3
分子量：478.29
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CAS No: 2762166-06-1
产品详情
生物活性：
ZIKV-IN-1 is a potent zika virus inhibitor with an EC50 of 2.8 μM and EC90 of 6.8 μM. ZIKV-IN-1 shows anti-ZIKV activity with low cytotoxicity. ZIKV-IN-1 shows a strong affinity to ZIKV RdRp domain. ZIKV-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体外研究：
ZIKV-IN-1 (compound 38) (0-80 μM) shows anti-ZIKV activity in a dose-dependent manner in A549 cells.ZIKV-IN-1 (5, 10, 25 μM; 48 h) decreases the expression of ZIKV E and cleaved caspase 3 protein.ZIKV-IN-1 (1.25, 2.5, 5, 10, 20 μM; 0-250 s) shows strong affinity to ZIKV RdRp domain (Kd=1.87 μM) in A549 cells.
ZIKV-IN-1 is a potent zika virus inhibitor with an EC50 of 2.8 μM and EC90 of 6.8 μM. ZIKV-IN-1 shows anti-ZIKV activity with low cytotoxicity. ZIKV-IN-1 shows a strong affinity to ZIKV RdRp domain. ZIKV-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体外研究：
ZIKV-IN-1 (compound 38) (0-80 μM) shows anti-ZIKV activity in a dose-dependent manner in A549 cells.ZIKV-IN-1 (5, 10, 25 μM; 48 h) decreases the expression of ZIKV E and cleaved caspase 3 protein.ZIKV-IN-1 (1.25, 2.5, 5, 10, 20 μM; 0-250 s) shows strong affinity to ZIKV RdRp domain (Kd=1.87 μM) in A549 cells.
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