产品
编 号：F755587
分子式：C23H18N2O4S
分子量：418.47
分子式：C23H18N2O4S
分子量：418.47
产品类型
规格
价格
是否有货
结构图
CAS No: 2760972-52-7
产品详情
生物活性：
Antiviral agent 35 (compound 4d) is an orally active and potent influenza virus inhibitor, acting function in the early stage of virus replication. Antiviral agent 35 inhibits ROS accumulation, autophagy and apoptosis induced by influenza virus, and also inhibits inflammatory response mediated by RIG-1 pathway in mouse model with pulmonary infection. Antiviral agent 35 shows little cytotoxicity with CC50 >800 μM in MDCK cells, and anti-H1N1 (A/Weiss/43) activity with EC50 of 2.28 μM.
体内研究：
Antiviral agent 35 (compound 4d) (25 mg/kg/d, 50 mg/kg/d, 100 mg/kg/d; by gavage; 2-6 d) 在 H1N1 感染后的第 2、4 和 6 天减轻小鼠的肺部炎症。
体外研究：
Antiviral agent 35 (compound 4d) (25 μM, 50 μM; 24-72 h) 抑制 MDCK 细胞中的流感病毒复制。
Antiviral agent 35 (compound 4d) is an orally active and potent influenza virus inhibitor, acting function in the early stage of virus replication. Antiviral agent 35 inhibits ROS accumulation, autophagy and apoptosis induced by influenza virus, and also inhibits inflammatory response mediated by RIG-1 pathway in mouse model with pulmonary infection. Antiviral agent 35 shows little cytotoxicity with CC50 >800 μM in MDCK cells, and anti-H1N1 (A/Weiss/43) activity with EC50 of 2.28 μM.
体内研究：
Antiviral agent 35 (compound 4d) (25 mg/kg/d, 50 mg/kg/d, 100 mg/kg/d; by gavage; 2-6 d) 在 H1N1 感染后的第 2、4 和 6 天减轻小鼠的肺部炎症。
体外研究：
Antiviral agent 35 (compound 4d) (25 μM, 50 μM; 24-72 h) 抑制 MDCK 细胞中的流感病毒复制。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备