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编 号:F755561
分子式:C25H19F2N5O3
分子量:475.45
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生物活性:
c-Met-IN-9, a 4-phenoxypyridine derivative, is a c-Met kinas inhibitor with an IC50 of 12 nM. c-Met-IN-9 induces cells apoptosis, and has antitumor activities.

体外研究:
c-Met-IN-9 (Compound T14) shows remarkable antiproliferative activities against MKN-45, A549 and H460 cell lines with IC50 values of 0.64 μM, 1.92 μM and 2.68 μM, respectively. c-Met-IN-9 could inhibit cells colony formation, induce cells apoptosis, and inhibit cells motility.
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