产品
编 号：F755550
分子式：C18H17ClN2O2
分子量：328.79
分子式：C18H17ClN2O2
分子量：328.79
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CAS No: 2759855-37-1
产品详情
生物活性：
HDAC1/MAO-B-IN-1 is a potent, selective and cross the blood-brain barrier HDAC1/MAO-B inhibitor with IC50 values of 21.4 nM and 99.0 nM for HDAC1 and MAO-B, respectively. HDAC1/MAO-B-IN-1 has the potential for the research of Alzheimer’s disease.
体内研究：
HDAC1/MAO-B-IN-1 (20 mg/kg; i.g.) exhibits favorable BBB (blood–brain barrier) permeability.HDAC1/MAO-B-IN-1 (15 mg/kg; i.p.) improves the learning and memory abilities of the ICR mice.Animal Model:6-8 weeks, ICR male mice
Dosage:20 mg/kg
Administration:I.g.
Result:Exhibited favorable BBB (blood–brain barrier) permeability.
Animal Model:20-25 g, ICR female mice
Dosage:15 mg/kg
Administration:I.p.; 15 consecutive days
Result:Improved the learning and memory abilities of the ICR mice.
体外研究：
HDAC1/MAO-B-IN-1 (compound 1f) shows inhibitory activities with IC50s of 99.0 nM, 9923.0 nM, 21.4 nM for hMAO-B, hMAO-A, hHDAC1, respectively.HDAC1/MAO-B-IN-1 (50 μM; 24 h) displays neuroprotective and inhibitory activity on ROS production in PC12 cells.
HDAC1/MAO-B-IN-1 is a potent, selective and cross the blood-brain barrier HDAC1/MAO-B inhibitor with IC50 values of 21.4 nM and 99.0 nM for HDAC1 and MAO-B, respectively. HDAC1/MAO-B-IN-1 has the potential for the research of Alzheimer’s disease.
体内研究：
HDAC1/MAO-B-IN-1 (20 mg/kg; i.g.) exhibits favorable BBB (blood–brain barrier) permeability.HDAC1/MAO-B-IN-1 (15 mg/kg; i.p.) improves the learning and memory abilities of the ICR mice.Animal Model:6-8 weeks, ICR male mice
Dosage:20 mg/kg
Administration:I.g.
Result:Exhibited favorable BBB (blood–brain barrier) permeability.
Animal Model:20-25 g, ICR female mice
Dosage:15 mg/kg
Administration:I.p.; 15 consecutive days
Result:Improved the learning and memory abilities of the ICR mice.
体外研究：
HDAC1/MAO-B-IN-1 (compound 1f) shows inhibitory activities with IC50s of 99.0 nM, 9923.0 nM, 21.4 nM for hMAO-B, hMAO-A, hHDAC1, respectively.HDAC1/MAO-B-IN-1 (50 μM; 24 h) displays neuroprotective and inhibitory activity on ROS production in PC12 cells.
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