产品
编 号：F755521
分子式：C24H20ClNO2
分子量：389.87
分子式：C24H20ClNO2
分子量：389.87
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CAS No: 2758520-84-0
产品详情
生物活性：
Antitumor agent-80 (compound 11) is an orally active and potent antitumor agent. Antitumor agent-80 induces apoptosis in tumor cells.
体内研究：
Antitumor agent-80 (compound 11) (40 mg/kg, Orally, twice a week, for 4 weeks) displays antitumor activity in vivo in the Mahlavu hepatocellular carcinoma and the MDA-MB-231 breast cancer xenograft models.Animal Model:Athymic nude mice (6-8 weeks old, with Mahlavu cells or MDA-MB-231 cells)
Dosage:40 mg/kg
Administration:Orally, twice a week, for 4 weeks
Result:In the Mahlavu xenografts, had a significant reduction (85%) in tumor volume. For MDA-MB-231 xenografts, resulted in about a 50% decrease in tumor volumes as compared to the control group.
体外研究：
Antitumor agent-80 (compound 11) (5 μM, 48 h) induces apoptosis and increase in PARP cleavage in tumor cells.Antitumor agent-80 (0-10 μM, 96 h) shows cell growth inhibitory activity against breast and hepatocellular carcinoma cell lines.Growth Inhibitory Activity of Antitumor agent-80 against Hepatocellular Carcinoma and Breast Cancer Cell Line Panel.hepatocellular carcinomaIC50 (μM) breast IC50 (μM)
Huh71.3MCF73.8
HepG22.1MDA-MB2312.0
SNU4751.7MDA-MB4682.8
Hep3B3.0SKBR33.5
FOCUS2.1ZR757.6
Hep408.6MCF10A12.1
PLC-PRF-59.5
Mahlavu3.2
Antitumor agent-80 (compound 11) is an orally active and potent antitumor agent. Antitumor agent-80 induces apoptosis in tumor cells.
体内研究：
Antitumor agent-80 (compound 11) (40 mg/kg, Orally, twice a week, for 4 weeks) displays antitumor activity in vivo in the Mahlavu hepatocellular carcinoma and the MDA-MB-231 breast cancer xenograft models.Animal Model:Athymic nude mice (6-8 weeks old, with Mahlavu cells or MDA-MB-231 cells)
Dosage:40 mg/kg
Administration:Orally, twice a week, for 4 weeks
Result:In the Mahlavu xenografts, had a significant reduction (85%) in tumor volume. For MDA-MB-231 xenografts, resulted in about a 50% decrease in tumor volumes as compared to the control group.
体外研究：
Antitumor agent-80 (compound 11) (5 μM, 48 h) induces apoptosis and increase in PARP cleavage in tumor cells.Antitumor agent-80 (0-10 μM, 96 h) shows cell growth inhibitory activity against breast and hepatocellular carcinoma cell lines.Growth Inhibitory Activity of Antitumor agent-80 against Hepatocellular Carcinoma and Breast Cancer Cell Line Panel.hepatocellular carcinomaIC50 (μM) breast IC50 (μM)
Huh71.3MCF73.8
HepG22.1MDA-MB2312.0
SNU4751.7MDA-MB4682.8
Hep3B3.0SKBR33.5
FOCUS2.1ZR757.6
Hep408.6MCF10A12.1
PLC-PRF-59.5
Mahlavu3.2
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