产品
编 号：F755519
分子式：C35H35N5O8
分子量：653.68
分子式：C35H35N5O8
分子量：653.68
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CAS No: 2758431-97-7
产品详情
生物活性：
MD13 is a macrophage migration inhibitory factor (MIF)-directed PROTAC with a Ki of 71 nM. MD13 can be used for cancer research.
体外研究：
MD13 degrades 91±5% and 71±7% MIF at 2 μM and 0.2 μM, respectively. MD13 induces MIF degradation through binding to E3 ligase cereblon.MD13 (0-20 μM; 72 h) inhibits cell proliferation of A549 cancer cells.MD13 (1-5 μM; 48 h) arrests cell cycle at G2/M phase in A549 cells.MD13 (2 μM; 6-48 h) inhibits ERK signaling.
MD13 is a macrophage migration inhibitory factor (MIF)-directed PROTAC with a Ki of 71 nM. MD13 can be used for cancer research.
体外研究：
MD13 degrades 91±5% and 71±7% MIF at 2 μM and 0.2 μM, respectively. MD13 induces MIF degradation through binding to E3 ligase cereblon.MD13 (0-20 μM; 72 h) inhibits cell proliferation of A549 cancer cells.MD13 (1-5 μM; 48 h) arrests cell cycle at G2/M phase in A549 cells.MD13 (2 μM; 6-48 h) inhibits ERK signaling.
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