产品
编 号：F755517
分子式：C20H23N5O2S
分子量：397.49
分子式：C20H23N5O2S
分子量：397.49
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CAS No: 2758411-61-7
产品详情
生物活性：
DC-BPi-11 is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 shows remarkable inhibition against leukemia cell proliferation.
体外研究：
DC-BPi-11 (0.1 nM-1 μM; 24 h) inhibits BPTF in human leukemia MV-4-11 cells with an EC50 value of 120 nM.DC-BPi-11 (0.01 μM-100 μM; 24 h) significantly inhibits the proliferation of human leukemia MV-4-11 cells (IC50=0.89 μM), and (2.5-20 μM; 24 h) decreases downstream oncogene expression.DC-BPi-11 (0.6-50 μM; 24 h) dose-dependently decreases c-Myc protein level.DC-BPi-11 is safety and shows minimal effects on normal cells.
DC-BPi-11 is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 shows remarkable inhibition against leukemia cell proliferation.
体外研究：
DC-BPi-11 (0.1 nM-1 μM; 24 h) inhibits BPTF in human leukemia MV-4-11 cells with an EC50 value of 120 nM.DC-BPi-11 (0.01 μM-100 μM; 24 h) significantly inhibits the proliferation of human leukemia MV-4-11 cells (IC50=0.89 μM), and (2.5-20 μM; 24 h) decreases downstream oncogene expression.DC-BPi-11 (0.6-50 μM; 24 h) dose-dependently decreases c-Myc protein level.DC-BPi-11 is safety and shows minimal effects on normal cells.
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