产品
编 号：F755494
分子式：C25H41FO5S
分子量：472.65
分子式：C25H41FO5S
分子量：472.65
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2758171-70-7
产品详情
生物活性：
AAA-10 is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC50s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH respectively.
体内研究：
AAA-10 (30 mg/kg; orally gavage daily for 5 days) decreases the abundances of deoxycholic acid (DCA) and lithocholic acid (LCA) in mice feces starting in day 2-5.AAA-10 (30 mg/kg) displays high colonic exposure and low gut permeability.Animal Model:10-11 weeks old male C57Bl/6J mice
Dosage:30 mg/kg
Administration:Orally gavaged once daily for 5 days
Result:Decreased the abundances of DCA and LCA in mice feces starting in day 2-5. Displayed high colonic exposure and low gut permeability.
体外研究：
AAA-10 (100 μM; 24 h) inhibits BSH activity in bacterial cultures, with IC50s of 74 nM, 901 nM for Gram-negative and Gram-positive bacteria, respectively. AAA-10 (20 μM; 2 h) significantly inhibits deconjugation ofglycochenodeoxycholic acid-d4or taurocholic acid-d4 substrates of human feces.
AAA-10 is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC50s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH respectively.
体内研究：
AAA-10 (30 mg/kg; orally gavage daily for 5 days) decreases the abundances of deoxycholic acid (DCA) and lithocholic acid (LCA) in mice feces starting in day 2-5.AAA-10 (30 mg/kg) displays high colonic exposure and low gut permeability.Animal Model:10-11 weeks old male C57Bl/6J mice
Dosage:30 mg/kg
Administration:Orally gavaged once daily for 5 days
Result:Decreased the abundances of DCA and LCA in mice feces starting in day 2-5. Displayed high colonic exposure and low gut permeability.
体外研究：
AAA-10 (100 μM; 24 h) inhibits BSH activity in bacterial cultures, with IC50s of 74 nM, 901 nM for Gram-negative and Gram-positive bacteria, respectively. AAA-10 (20 μM; 2 h) significantly inhibits deconjugation ofglycochenodeoxycholic acid-d4or taurocholic acid-d4 substrates of human feces.
产品资料
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