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编 号：F755478
分子式：C39H50F2N10O13P2
分子量：966.82
分子式：C39H50F2N10O13P2
分子量：966.82
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CAS No: 2757762-91-5
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生物活性：
Antitumor agent-114 is a potent stimulator of interferon genes (STING) agonist. Antitumor agent-114 activates immunity and reduces tumor volume in a mouse model of breast cancer. Antitumor agent-114 can be used for immunity and cancer diseases research.
体内研究：
Antitumor agent-114 (compound 14c) (2, 0.67, 0.22 mg/kg, 分别于第 1, 4 和 7 天进行鞘内注射) 在 4T1 荷瘤小鼠模型中通过全身免疫激活介导肿瘤完全消退。Animal Model:4T1 tumor-bearing mice model
Dosage:2, 0.67, 0.22 mg/kg
Administration:Intratumoral (i.t.)
Result:Reached 80 and 70% tumor growth inhibition (TGI) in the groups treated with 2 and 0.67 mg/kg.Induced tumor regression in 7 of 8 mice at a dose of 2 mg/kg.
Antitumor agent-114 is a potent stimulator of interferon genes (STING) agonist. Antitumor agent-114 activates immunity and reduces tumor volume in a mouse model of breast cancer. Antitumor agent-114 can be used for immunity and cancer diseases research.
体内研究：
Antitumor agent-114 (compound 14c) (2, 0.67, 0.22 mg/kg, 分别于第 1, 4 和 7 天进行鞘内注射) 在 4T1 荷瘤小鼠模型中通过全身免疫激活介导肿瘤完全消退。Animal Model:4T1 tumor-bearing mice model
Dosage:2, 0.67, 0.22 mg/kg
Administration:Intratumoral (i.t.)
Result:Reached 80 and 70% tumor growth inhibition (TGI) in the groups treated with 2 and 0.67 mg/kg.Induced tumor regression in 7 of 8 mice at a dose of 2 mg/kg.
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