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编 号:F755468
分子式:C32H31FN6O4
分子量:582.62
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生物活性:
Immuno modulator-1 (compound 22) inhibits TNFα and IL-2 secretion in human peripheral blood mononuclear cells (hPBMC), with IC50 values of 4.7 and 26 nM, respectively. Immuno modulator-1 shows hERG potassium channel blocking effect, with Inhibitory percentage of 20% at 3 μM.

体内研究:
Immuno modulator-1 (compound 22) (1 mg/kg (IV), 5 mg/kg (PO); once) 在雄性 Sprague-Dawley 大鼠中的口服生物利用度为30%。Animal Model:Male Sprague-Dawley rats
Dosage:1 mg/kg (IV), 5 mg/kg (PO)
Administration:IV (2 mL/kg), PO (10 mL/kg); once (Pharmacokinetic Analysis)
Result:Pharmacokinetic Parameters of Immuno modulator-1 in male Sprague-Dawley rats.IV (1 mg/kg) PO (5 mg/kg)
Cmax (ng/mL)1437
AUC0-24 (ng/mL?h)13029
CL (mL/min/kg)2.2
Vss (L/kg)0.36
F (%)30%


体外研究:
Immuno modulator-1 (compound 22) 抑制 NCI-H929 人骨髓瘤细胞的增殖,IC50 为 0.6 nM。
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