产品
编 号：F755453
分子式：C24H18FN3O
分子量：383.42
分子式：C24H18FN3O
分子量：383.42
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CAS No: 2757145-67-6
产品详情
生物活性：
Antitumor agent-53 is a potent antitumor agent. Antitumor agent-53 induces cell cycle arrest at the G2/M phase. Antitumor agent-53 inhibits the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells. Antitumor agent-53 has the potential for the research of gastrointestinal tumors.
体外研究：
Antitumor agent-53 (compound 6f) (0, 0.22, 0.67, 2, 6, 18 μM; 72 h) shows anti-proliferation activity with IC50s of 3.10, 0.37, 4.01, >18, 7.87, 9.11 μM for HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells.Antitumor agent-53 (0.15, 0.3, 0.6 μM) shows anti-proliferative activity in HGC-27 and HT-29 cells with a dose-dependent manner.Antitumor agent-53 (100, 200 μM) shows a certain inhibitory activity against Topo I at 200 μM.Antitumor agent-53 (0.1, 0.3, 0.9 μM; 24 h) induces cell cycle arrest at the G2/M phase in HGC-27, HT-29 cells.Antitumor agent-53 (0.1, 0.3, 0.9, 2.7 μM; 24 h) induces the apoptosis of HGC-27 and HT-29 cells in a concentration-dependent manner.Antitumor agent-53 (0.15, 0.3, 0.6 μM; 24 h) inhibits the migration and invasion of HGC-27 cells in a concentration-dependent manner.Antitumor agent-53 (0.1, 0.3, 0.9 μM; 24 h) suppresses the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells.
Antitumor agent-53 is a potent antitumor agent. Antitumor agent-53 induces cell cycle arrest at the G2/M phase. Antitumor agent-53 inhibits the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells. Antitumor agent-53 has the potential for the research of gastrointestinal tumors.
体外研究：
Antitumor agent-53 (compound 6f) (0, 0.22, 0.67, 2, 6, 18 μM; 72 h) shows anti-proliferation activity with IC50s of 3.10, 0.37, 4.01, >18, 7.87, 9.11 μM for HGC-27, HT-29, HepG-2, A549, MCF7, GES-1 cells.Antitumor agent-53 (0.15, 0.3, 0.6 μM) shows anti-proliferative activity in HGC-27 and HT-29 cells with a dose-dependent manner.Antitumor agent-53 (100, 200 μM) shows a certain inhibitory activity against Topo I at 200 μM.Antitumor agent-53 (0.1, 0.3, 0.9 μM; 24 h) induces cell cycle arrest at the G2/M phase in HGC-27, HT-29 cells.Antitumor agent-53 (0.1, 0.3, 0.9, 2.7 μM; 24 h) induces the apoptosis of HGC-27 and HT-29 cells in a concentration-dependent manner.Antitumor agent-53 (0.15, 0.3, 0.6 μM; 24 h) inhibits the migration and invasion of HGC-27 cells in a concentration-dependent manner.Antitumor agent-53 (0.1, 0.3, 0.9 μM; 24 h) suppresses the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells.
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