产品
编 号：F755357
分子式：C22H24ClF2N5O
分子量：447.91
分子式：C22H24ClF2N5O
分子量：447.91
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2751586-94-2
产品详情
生物活性：
Ganaplacide (KAF156) hydrochloride is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide hydrochloride is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide hydrochloride is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite.
体内研究：
KAF156 对成熟的恶性疟原虫 配子体表现出杀灭活性，从而阻止寄生虫传播给按蚊蚊子。 Ganaplacide hydrochloride (KAF156) hydrochloride (1-15 mg/kg；口服) 在疟疾的因果预防小鼠模型中具有充分的保护作用。Animal Model:Mice (causal prophylactic rodent malaria model)
Dosage:1-15 mg/kg
Administration:p.o.
Result:A single oral dose of 10 mg of KAF156/kg administered 2 h before infection was fully protective.
体外研究：
Ganaplacide hydrochloride (KAF156) hydrochloride 显示出血液裂殖体杀活性，针对 P. falciparum 药物敏感和耐药菌株的 50% 抑制浓度为 6 至 17.4 nM。
Ganaplacide (KAF156) hydrochloride is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide hydrochloride is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide hydrochloride is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite.
体内研究：
KAF156 对成熟的恶性疟原虫 配子体表现出杀灭活性，从而阻止寄生虫传播给按蚊蚊子。 Ganaplacide hydrochloride (KAF156) hydrochloride (1-15 mg/kg；口服) 在疟疾的因果预防小鼠模型中具有充分的保护作用。Animal Model:Mice (causal prophylactic rodent malaria model)
Dosage:1-15 mg/kg
Administration:p.o.
Result:A single oral dose of 10 mg of KAF156/kg administered 2 h before infection was fully protective.
体外研究：
Ganaplacide hydrochloride (KAF156) hydrochloride 显示出血液裂殖体杀活性，针对 P. falciparum 药物敏感和耐药菌株的 50% 抑制浓度为 6 至 17.4 nM。
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