产品
编 号:F755357
分子式:C22H24ClF2N5O
分子量:447.91
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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生物活性:
Ganaplacide (KAF156) hydrochloride is a first-in-class, orally active imidazolopiperazine antimalarial agent. Ganaplacide hydrochloride is active against a broad range of Plasmodium species, including drug-resistant parasites. Ganaplacide hydrochloride is parasiticidal against both asexual and sexual blood stages as well as the liver stages of the parasite.

体内研究:
KAF156 对成熟的恶性疟原虫 配子体表现出杀灭活性,从而阻止寄生虫传播给按蚊蚊子。 Ganaplacide hydrochloride (KAF156) hydrochloride (1-15 mg/kg;口服) 在疟疾的因果预防小鼠模型中具有充分的保护作用。Animal Model:Mice (causal prophylactic rodent malaria model)
Dosage:1-15 mg/kg
Administration:p.o.
Result:A single oral dose of 10 mg of KAF156/kg administered 2 h before infection was fully protective.

体外研究:
Ganaplacide hydrochloride (KAF156) hydrochloride 显示出血液裂殖体杀活性,针对 P. falciparum 药物敏感和耐药菌株的 50% 抑制浓度为 6 至 17.4 nM。
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