产品
编 号：F755334
分子式：C16H18ClFN2O2
分子量：324.78
分子式：C16H18ClFN2O2
分子量：324.78
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CAS No: 2750254-34-1
产品详情
生物活性：
HBV-IN-20 is a potent and oral active HBV inhibitor with an EC50 of 0.46 μM. HBV-IN-20 is a typical type II CpAM (core protein assembly modulators).
体内研究：
HBV-IN-20 (3 mg/kg for i.v.; 10 mg/kg for p.o.) shows 69% of oral bioavailability.Pharmacokinetic Parameters of HBV-IN-20 in mouse.CompdAdmin. Cl-obs (mL/min/kg) T1/2 (hr) AUClast (h*ng/mL)Vss-obs (L/kg)Cmax (ng/mL)F (%)
61i.v.25.50.619520.8
p.o. 0.74516 272769
Mouse; 3 mg/kg for i.v.; 10 mg/kg for p.o.Animal Model:Mouse
Dosage:
Administration:3 mg/kg for i.v.; 10 mg/kg for p.o.
Result:Showed 69% of oral bioavailability.
体外研究：
HBV-IN-20 (compound 61) (5 μM; 6 days) is a typical type II CpAM (core protein assembly modula tors).
HBV-IN-20 is a potent and oral active HBV inhibitor with an EC50 of 0.46 μM. HBV-IN-20 is a typical type II CpAM (core protein assembly modulators).
体内研究：
HBV-IN-20 (3 mg/kg for i.v.; 10 mg/kg for p.o.) shows 69% of oral bioavailability.Pharmacokinetic Parameters of HBV-IN-20 in mouse.CompdAdmin. Cl-obs (mL/min/kg) T1/2 (hr) AUClast (h*ng/mL)Vss-obs (L/kg)Cmax (ng/mL)F (%)
61i.v.25.50.619520.8
p.o. 0.74516 272769
Mouse; 3 mg/kg for i.v.; 10 mg/kg for p.o.Animal Model:Mouse
Dosage:
Administration:3 mg/kg for i.v.; 10 mg/kg for p.o.
Result:Showed 69% of oral bioavailability.
体外研究：
HBV-IN-20 (compound 61) (5 μM; 6 days) is a typical type II CpAM (core protein assembly modula tors).
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