产品
编 号：F755300
分子式：C18H28N2O6S2
分子量：432.55
分子式：C18H28N2O6S2
分子量：432.55
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CAS No: 2749554-00-3
产品详情
生物活性：
DX2-201 is a potent and selective oxidative phosphorylation (OXPHOS) complex I inhibitor with an IC50 of 312 nM. DX2-201 has anticancer effects.
体外研究：
DX2-201 (cmpound 2) potently inhibits the mitochondrial function by depleting ATP production in MIA PaCa-2 cells when glucose is replaced by galactose in the medium, a condition that forces mammalian cells to rely on OXPHOS.DX2-201 depletes ATP production with an IC50 value of 118.5 nM in the galactose-containing medium.DX2-201 significantly inhibits OXPHOS complex I as determined by its inhibition of oxidation of NADH to NAD+ in the NAD/NADH assay (IC50 = 312 nM).DX2-201 inhibits MIA PaCa-2 and BxPC-3 cells growth with IC50 values of 0.4 μM and 0.6 μM, respectively.
DX2-201 is a potent and selective oxidative phosphorylation (OXPHOS) complex I inhibitor with an IC50 of 312 nM. DX2-201 has anticancer effects.
体外研究：
DX2-201 (cmpound 2) potently inhibits the mitochondrial function by depleting ATP production in MIA PaCa-2 cells when glucose is replaced by galactose in the medium, a condition that forces mammalian cells to rely on OXPHOS.DX2-201 depletes ATP production with an IC50 value of 118.5 nM in the galactose-containing medium.DX2-201 significantly inhibits OXPHOS complex I as determined by its inhibition of oxidation of NADH to NAD+ in the NAD/NADH assay (IC50 = 312 nM).DX2-201 inhibits MIA PaCa-2 and BxPC-3 cells growth with IC50 values of 0.4 μM and 0.6 μM, respectively.
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