产品
编 号：F755175
分子式：C13H15F4NO
分子量：277.26
分子式：C13H15F4NO
分子量：277.26
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 2741956-55-6
产品详情
生物活性：
BAY-390 is a selective, across species active and brain penetrating TRPA1 inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50s of 16, 82, 63 and 35 nM, respectively. BAY-390 can be used for the research of inflammation.
体内研究：
BAY-390 (30 and 90 mg/kg; p.o.; BID for 10 days) effects the neuropathic pain in vivo.BAY-390 reduces visceral pain in rat cyclophosphamide induced cystitis models.BAY-390 shows efficacy in inflammatory pain and neurogenic inflammation models.Animal Model:Nrodent animals with neuropathic pain
Dosage:30 and 90 mg/kg
Administration:Oral gavage; 30 and 90 mg/kg; twice daily for 10 days
Result:Effectively reduced the neuropathic pain in rodent neuropathic pain model.
体外研究：
BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50s of 16, 82, 63 and 35 nM, respectively.BAY-390 inhibits mTRPA1, gpTRPA1, dogTRPA1 and monkeyTRPA1 with IC50s of 73, 68, 81 and 19 nM, respectively.
BAY-390 is a selective, across species active and brain penetrating TRPA1 inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50s of 16, 82, 63 and 35 nM, respectively. BAY-390 can be used for the research of inflammation.
体内研究：
BAY-390 (30 and 90 mg/kg; p.o.; BID for 10 days) effects the neuropathic pain in vivo.BAY-390 reduces visceral pain in rat cyclophosphamide induced cystitis models.BAY-390 shows efficacy in inflammatory pain and neurogenic inflammation models.Animal Model:Nrodent animals with neuropathic pain
Dosage:30 and 90 mg/kg
Administration:Oral gavage; 30 and 90 mg/kg; twice daily for 10 days
Result:Effectively reduced the neuropathic pain in rodent neuropathic pain model.
体外研究：
BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50s of 16, 82, 63 and 35 nM, respectively.BAY-390 inhibits mTRPA1, gpTRPA1, dogTRPA1 and monkeyTRPA1 with IC50s of 73, 68, 81 and 19 nM, respectively.
产品资料
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