产品
编 号：F754989
分子式：C23H21ClFN3O5
分子量：473.88
分子式：C23H21ClFN3O5
分子量：473.88
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规格
价格
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CAS No: 2725075-05-6
产品详情
生物活性：
Chitin synthase inhibitor 12 is a chitin synthase inhibitor. Chitin synthase inhibitor 12 shows excellent inhibitory activity with an IC50 value of 0.16 mM. Chitin synthase inhibitor 12 also is a broad-spectrum antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 12 can be used for the research of invasive fungal infections (IFIs).
体外研究：
Chitin synthase inhibitor 12 (compound 9t) (300 ug/mL) has good inhibitory activity against chitin synthase with an IC50 value of 0.16 mM.Chitin synthase inhibitor 12 has antifungal activity for C. albicans, A. flavus, A. fumigatus and C. neoformans with MIC values of 64 μg/mL, 16 μg/mL, 64 μg/mL and 64 μg/mL, respectively.Chitin synthase inhibitor 12 has broad-spectrum antifungal activity in vitro and has additive or synergistic effects combined with fluconazole.Chitin synthase inhibitor 12 is related to the disruption of cell wall architecture.
Chitin synthase inhibitor 12 is a chitin synthase inhibitor. Chitin synthase inhibitor 12 shows excellent inhibitory activity with an IC50 value of 0.16 mM. Chitin synthase inhibitor 12 also is a broad-spectrum antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 12 can be used for the research of invasive fungal infections (IFIs).
体外研究：
Chitin synthase inhibitor 12 (compound 9t) (300 ug/mL) has good inhibitory activity against chitin synthase with an IC50 value of 0.16 mM.Chitin synthase inhibitor 12 has antifungal activity for C. albicans, A. flavus, A. fumigatus and C. neoformans with MIC values of 64 μg/mL, 16 μg/mL, 64 μg/mL and 64 μg/mL, respectively.Chitin synthase inhibitor 12 has broad-spectrum antifungal activity in vitro and has additive or synergistic effects combined with fluconazole.Chitin synthase inhibitor 12 is related to the disruption of cell wall architecture.
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