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编 号：F754955
分子式：C18H30O
分子量：262.43
分子式：C18H30O
分子量：262.43
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CAS No: 272126-07-5
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生物活性：
4-Butyl-alpha-agarofuran (AF 5) is an anxiolytic and antidepressant agent. 4-Butyl-alpha-agarofuran a α-agarofuran derivative that can be isolated from Gharu-wood. 4-Butyl-alpha-agarofuran can be used for the research of neurological disease research.
体内研究：
4-Butyl-alpha-agarofuran (0.5-10 mg/kg；腹腔注射，1 次) 在社交互动测试中显示出抗焦虑作用，显著降低纹状体、皮层和中脑的血清素 (5-HT) 水平。Animal Model:Male Wistar rats
Dosage:0.5, 1.0, 2.0, 4.0, 5.0 and 10.0 mg/kg
Administration:Intraperitoneal injection; 0.5, 1.0, 2.0, 4.0, 5.0 and 10.0 mg/kg; once
Result:Dose-dependently prolonged the total time spent in social interaction test at a dose range of 0.5-2.0 mg/kg. Decreased the 5-HT levels in brain tissues, decreased dopamine levels of in rat striatum and midbrain and also reduced the cortical level of epinephrine at a dose of 5 mg/kg after acute administration. Decresed the extracellular dopamine level in the striatum at a dose of 10 mg/kg.
体外研究：
在人肝微粒体培养体系中，4-Butyl-alpha-agarofuran (2 mg) 在 100 分钟内完全代谢为羟基衍生物 I 和羰基衍生物 II。
4-Butyl-alpha-agarofuran (AF 5) is an anxiolytic and antidepressant agent. 4-Butyl-alpha-agarofuran a α-agarofuran derivative that can be isolated from Gharu-wood. 4-Butyl-alpha-agarofuran can be used for the research of neurological disease research.
体内研究：
4-Butyl-alpha-agarofuran (0.5-10 mg/kg；腹腔注射，1 次) 在社交互动测试中显示出抗焦虑作用，显著降低纹状体、皮层和中脑的血清素 (5-HT) 水平。Animal Model:Male Wistar rats
Dosage:0.5, 1.0, 2.0, 4.0, 5.0 and 10.0 mg/kg
Administration:Intraperitoneal injection; 0.5, 1.0, 2.0, 4.0, 5.0 and 10.0 mg/kg; once
Result:Dose-dependently prolonged the total time spent in social interaction test at a dose range of 0.5-2.0 mg/kg. Decreased the 5-HT levels in brain tissues, decreased dopamine levels of in rat striatum and midbrain and also reduced the cortical level of epinephrine at a dose of 5 mg/kg after acute administration. Decresed the extracellular dopamine level in the striatum at a dose of 10 mg/kg.
体外研究：
在人肝微粒体培养体系中，4-Butyl-alpha-agarofuran (2 mg) 在 100 分钟内完全代谢为羟基衍生物 I 和羰基衍生物 II。
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