产品
编 号：F754835
分子式：C18H14O8
分子量：358.3
分子式：C18H14O8
分子量：358.3
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CAS No: 2710376-48-8
产品详情
生物活性：
Antioxidant agent-3 (Compound 14q), an potent antioxidant, displays potent DPPH radicals scavenging activity and ABTS+?scavenging activity with IC50s of 26.58 and 30.31?μM, respectively. Antioxidant agent-3 (Compound 14q) increases?reactive oxygen species?(ROS), superoxide dismutase?(SOD)?and glutathione (GSH), and reduced?lactate dehydrogenase?(LDH)?in H2O2-treated HepG2 cells.
体外研究：
Antioxidant agent-3 (Compound 14q) exhibits good activity in DPPH radicals scavenging and ABTS +? scavenging with the values of IC50 is 26.58 μM and 30.31 μM respectively.Antioxidant agent-3 shows low cytotoxicity in human normal WI-38 (IC50 > 100 μM) and GES (IC50 > 200 μM) cells. Antioxidant agent-3 can enhance viability of H2O2-induced HepG2 cells. Antioxidant agent-3 decreases the apoptotic percentage of HepG2 cells.Antioxidant agent-3 reduces the ROS produce and LDH release, improves GSH and SOD levels in H2O2-treated HepG2 cells, and exhibits more stability in methanol solution.
Antioxidant agent-3 (Compound 14q), an potent antioxidant, displays potent DPPH radicals scavenging activity and ABTS+?scavenging activity with IC50s of 26.58 and 30.31?μM, respectively. Antioxidant agent-3 (Compound 14q) increases?reactive oxygen species?(ROS), superoxide dismutase?(SOD)?and glutathione (GSH), and reduced?lactate dehydrogenase?(LDH)?in H2O2-treated HepG2 cells.
体外研究：
Antioxidant agent-3 (Compound 14q) exhibits good activity in DPPH radicals scavenging and ABTS +? scavenging with the values of IC50 is 26.58 μM and 30.31 μM respectively.Antioxidant agent-3 shows low cytotoxicity in human normal WI-38 (IC50 > 100 μM) and GES (IC50 > 200 μM) cells. Antioxidant agent-3 can enhance viability of H2O2-induced HepG2 cells. Antioxidant agent-3 decreases the apoptotic percentage of HepG2 cells.Antioxidant agent-3 reduces the ROS produce and LDH release, improves GSH and SOD levels in H2O2-treated HepG2 cells, and exhibits more stability in methanol solution.
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