产品
编 号：F754819
分子式：C27H29N3O2
分子量：427.54
分子式：C27H29N3O2
分子量：427.54
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CAS No: 2708270-99-7
产品详情
生物活性：
SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC50 value of 0.0399 μg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice.
体内研究：
SIMR3030 (25、50、100 mg/kg；I.p.；每日一次，持续 14 天) 在实验小鼠模型中表现出较好的安全性。Animal Model:18-25 g, adult female Balb/c mice
Dosage:25, 50, 100 mg/kg
Administration:I.p.; daily for 14 days
Result:Showed no signs of toxicity or weight loss were noticed during 12.5 and 25 mg/kg multiple-dose studies for 14 days, no signs of toxicity or weight loss were noticed during 12.5 and 25 mg/kg multiple-dose studies for 14 days.
体外研究：
SIMR3030 (0-100 μg/mL) 显示抗病毒活性，对 SARS-CoV-2 和 MERS-CoV 的 IC50 值分别为 12.1、6.206 μg/mL。SIMR3030 (20 μg/mL; 1, 6, 12 h) 降低 Caco-2 细胞中的 SARS-CoV spike、ORF1b、IFN-α、IL-6 mRNA 表达水平。
SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC50 value of 0.0399 μg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice.
体内研究：
SIMR3030 (25、50、100 mg/kg；I.p.；每日一次，持续 14 天) 在实验小鼠模型中表现出较好的安全性。Animal Model:18-25 g, adult female Balb/c mice
Dosage:25, 50, 100 mg/kg
Administration:I.p.; daily for 14 days
Result:Showed no signs of toxicity or weight loss were noticed during 12.5 and 25 mg/kg multiple-dose studies for 14 days, no signs of toxicity or weight loss were noticed during 12.5 and 25 mg/kg multiple-dose studies for 14 days.
体外研究：
SIMR3030 (0-100 μg/mL) 显示抗病毒活性，对 SARS-CoV-2 和 MERS-CoV 的 IC50 值分别为 12.1、6.206 μg/mL。SIMR3030 (20 μg/mL; 1, 6, 12 h) 降低 Caco-2 细胞中的 SARS-CoV spike、ORF1b、IFN-α、IL-6 mRNA 表达水平。
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