产品
编 号：F754818
分子式：C22H18O14S
分子量：538.43
分子式：C22H18O14S
分子量：538.43
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CAS No: 2708237-76-5
产品详情
生物活性：
EGCG-4″-sulfate is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate sulfate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. EGCG-4″-sulfate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma.
体内研究：
EGCG-4″-sulfate (Intragastrical administration, 5-20 mg/kg, once daily for 14 days, orthotopic transplant model) decreases tumors growth.EGCG-4″-sulfate (Injected into the mouse lower gingiva, a single dose of 0.5 mg/mouse, experimental periodontitis model) decreases inhibits the LPS-induced loss of bone mineral density (BMD).Animal Model:Orthotopic transplant BALB/c nude mice model
Dosage:5, 10, and 20 mg/kg, once daily for 14 days.
Administration:Intragastrical administration.
Result:Inhibited tumors growth with no liver or lung metastases.
Animal Model:Model of experimental periodontitis, LPS (25 μg/mouse)
Dosage:0.5 mg/mouse, a single dose.
Administration:Injected into the mouse lower gingiva
Result:Inhibited the LPS-induced loss of bone mineral density (BMD) in mice.
体外研究：
EGCG-4″-sulfate (10-60 μM) inhibits the growth of FB-2 and WRO cells in a dose-dependent manner.EGCG-4″-sulfate (10-60 μM, 0-24 h) reduces cyclin D1 and phosphorylation of AKT and ERK1/2, and increases p21 and p53 expression.EGCG-4″-sulfate (10-60 μM, 12 h) reduces cell motility and migration.EGCG-4″-sulfate (0-20 μM, 0-20 min approximately) inhibits GLUD1/2 and IDH1 activity in a concentration and time-dependent way (biochemical assays).EGCG-4″-sulfate (0-35 μg/mL, 24-72 h) inhibits the proliferation of colorectal cancer cells (LoVo, SW480, HT-29, HCT-8 cells), increases cell apoptosis and blocks cells at the G0/G1 phase.EGCG-4″-sulfate (30 μM, 3-24 h) suppresses the expression of COX-2 and mPGES-1 mRNAs, prostaglandin E2 production in LPS-induced osteoblasts.
EGCG-4″-sulfate is a major polyphenol in green tea, which can inhibit cell proliferation and induce cell apoptosis. (-)-Epigallocatechin Gallate sulfate inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity. EGCG-4″-sulfate has a potent anticancer, antioxidant and anti-inflammatory properties against various types of cancers such as colorectal cancer, myeloid leukemia, thyroid carcinoma.
体内研究：
EGCG-4″-sulfate (Intragastrical administration, 5-20 mg/kg, once daily for 14 days, orthotopic transplant model) decreases tumors growth.EGCG-4″-sulfate (Injected into the mouse lower gingiva, a single dose of 0.5 mg/mouse, experimental periodontitis model) decreases inhibits the LPS-induced loss of bone mineral density (BMD).Animal Model:Orthotopic transplant BALB/c nude mice model
Dosage:5, 10, and 20 mg/kg, once daily for 14 days.
Administration:Intragastrical administration.
Result:Inhibited tumors growth with no liver or lung metastases.
Animal Model:Model of experimental periodontitis, LPS (25 μg/mouse)
Dosage:0.5 mg/mouse, a single dose.
Administration:Injected into the mouse lower gingiva
Result:Inhibited the LPS-induced loss of bone mineral density (BMD) in mice.
体外研究：
EGCG-4″-sulfate (10-60 μM) inhibits the growth of FB-2 and WRO cells in a dose-dependent manner.EGCG-4″-sulfate (10-60 μM, 0-24 h) reduces cyclin D1 and phosphorylation of AKT and ERK1/2, and increases p21 and p53 expression.EGCG-4″-sulfate (10-60 μM, 12 h) reduces cell motility and migration.EGCG-4″-sulfate (0-20 μM, 0-20 min approximately) inhibits GLUD1/2 and IDH1 activity in a concentration and time-dependent way (biochemical assays).EGCG-4″-sulfate (0-35 μg/mL, 24-72 h) inhibits the proliferation of colorectal cancer cells (LoVo, SW480, HT-29, HCT-8 cells), increases cell apoptosis and blocks cells at the G0/G1 phase.EGCG-4″-sulfate (30 μM, 3-24 h) suppresses the expression of COX-2 and mPGES-1 mRNAs, prostaglandin E2 production in LPS-induced osteoblasts.
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