产品
编 号：F754780
分子式：C26H33FN2O4S
分子量：488.61
分子式：C26H33FN2O4S
分子量：488.61
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CAS No: 2703867-74-5
产品详情
生物活性：
BM635 mesylate is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 mesylate has a MIC50?of 0.6 μM against M. tuberculosis ?H37Rv. BM635 mesylate significantly improves the bioavailability compared to free-base BM635.
体内研究：
BM635 mesylate (oral administration; 50 mg/kg) results in gradual elevations in blood up to a Cmax of 2970 ng/ml with Tmax of 0.8 hour, it has a improved solubility compared to BM635 hydrochloride. In addition, BM635-Mes significantly improves the bioavailability with a AUC 4 times higher than free-base BM635.
BM635 mesylate is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 mesylate has a MIC50?of 0.6 μM against M. tuberculosis ?H37Rv. BM635 mesylate significantly improves the bioavailability compared to free-base BM635.
体内研究：
BM635 mesylate (oral administration; 50 mg/kg) results in gradual elevations in blood up to a Cmax of 2970 ng/ml with Tmax of 0.8 hour, it has a improved solubility compared to BM635 hydrochloride. In addition, BM635-Mes significantly improves the bioavailability with a AUC 4 times higher than free-base BM635.
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