产品
编 号：F754743
分子式：C24H28N2O
分子量：360.49
分子式：C24H28N2O
分子量：360.49
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CAS No: 2700896-73-5
产品详情
生物活性：
BChE-IN-13 (Compound 17c) is an orally active, potent and selective Butyrylcholinesterase (BChE) inhibitor with IC50s of 0.22 and 0.016 μM for eqBChE and hBChE, respectively. BChE-IN-13 can improve memory and cognitive impairments, and be used in Alzheimer’s disease (AD) research.
体内研究：
BChE-IN-13 (oral gavage; 15 mg/kg; once daily; 6 d) shows the improvement in memory and cognitive function in Aβ1-42 induced AD-like disorder mice.Animal Model:ICR mice intracerebroventricularly (icv) injected with oligomerized Aβ1-42
Dosage:15 mg/kg
Administration:Oral gavage; 15 mg/kg; once daily; 6 days
Result:Improved the memory and cognitive function, and showed a shorter latency compared with Donepezil.
体外研究：
BChE-IN-13 (5-100 μM; 24 h) shows weak toxicity to SH-SY5Y, PC-12 and HT-22, and shows high mortality to BV2 cells.BChE-IN-13 shows excellent blood brain barrier permeation using a parallel artificial membrane permeability assay experiment (PAMPA).
BChE-IN-13 (Compound 17c) is an orally active, potent and selective Butyrylcholinesterase (BChE) inhibitor with IC50s of 0.22 and 0.016 μM for eqBChE and hBChE, respectively. BChE-IN-13 can improve memory and cognitive impairments, and be used in Alzheimer’s disease (AD) research.
体内研究：
BChE-IN-13 (oral gavage; 15 mg/kg; once daily; 6 d) shows the improvement in memory and cognitive function in Aβ1-42 induced AD-like disorder mice.Animal Model:ICR mice intracerebroventricularly (icv) injected with oligomerized Aβ1-42
Dosage:15 mg/kg
Administration:Oral gavage; 15 mg/kg; once daily; 6 days
Result:Improved the memory and cognitive function, and showed a shorter latency compared with Donepezil.
体外研究：
BChE-IN-13 (5-100 μM; 24 h) shows weak toxicity to SH-SY5Y, PC-12 and HT-22, and shows high mortality to BV2 cells.BChE-IN-13 shows excellent blood brain barrier permeation using a parallel artificial membrane permeability assay experiment (PAMPA).
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