产品
编 号:F754699
分子式:C40H43ClFN5O5S
分子量:760.32
产品类型
结构图
CAS No: 2697112-32-4
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产品详情
生物活性:
JNJ-4355 is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with KI of 18 pM. JNJ-4355 shows antitumor activity.
体内研究:
JNJ-4355 (IV , single) shows complete tumor regression in a mouse MOLP8 (multiple myeloma) xenograft.
体外研究:
JNJ-4355 shows promising in vitro potency data in cancer cell lines and AML patient-derived samples.