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编 号:F754699
分子式:C40H43ClFN5O5S
分子量:760.32
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生物活性:
JNJ-4355 is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with KI of 18 pM. JNJ-4355 shows antitumor activity.

体内研究:
JNJ-4355 (IV , single) shows complete tumor regression in a mouse MOLP8 (multiple myeloma) xenograft.

体外研究:
JNJ-4355 shows promising in vitro potency data in cancer cell lines and AML patient-derived samples.
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