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编 号：F754612
分子式：C26H34N2O5S
分子量：486.62
分子式：C26H34N2O5S
分子量：486.62
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CAS No: 2685786-29-0
产品详情
生物活性：
Neuraminidase-IN-10 is a potent neuraminidase (NA) inhibitor with ?anti-influenza?activity. Neuraminidase-IN-10 is against H1N1, H5N1, and H5N8 with IC50 values of 2.6 nM, 5.1 nM, and 1.65 nM, respectively.
体内研究：
Neuraminidase-IN-10 (0.156 mM-10 mM; injected into the eggs) showed good protection against both H5N1 and H5N8 strains in a dose-dependent manner in a chicken embryonated egg model .Animal Model:SPF Chicken Embryonated Egg
Dosage:0.156 mM; 0.625 mM; 2.5 mM; 10 mM
Administration:Injected into the egg
Result:were not as effective as OSC in this infection model, but also exhibited a certain therapeutic effect.The survival rates of?Neuraminidase-IN-10?(H5N1: 100 and 40%, respectively; H5N8: 100 and 100%, respectively)? at 2.5 mM and 10 mM.
体外研究：
Neuraminidase-IN-10 displays promising anti-influenza virus activity with EC50 value of 7.28 and 0.71μM for H5N1 and H5N8, respectively in CEFs. Neuraminidase-IN-10 displays anti-influenza virus activity with EC50 values of 0.04?±?0.04 and 28.70?±?1.61 μM, respectively in MDCK Cells.Metabolic stability is an important indicator for the assessment of drug candidates. Neuraminidase-IN-10 exhibits a T1/2?(min), CLint(mic) (μL/min/kg), CLint (liver) (mL/min/kg) and remaining (T=60?min)(%) values of 120.5 min, 11.5 μL/min/kg, 10.4 mL/min/kg and 73.8 mins, respectively.
Neuraminidase-IN-10 is a potent neuraminidase (NA) inhibitor with ?anti-influenza?activity. Neuraminidase-IN-10 is against H1N1, H5N1, and H5N8 with IC50 values of 2.6 nM, 5.1 nM, and 1.65 nM, respectively.
体内研究：
Neuraminidase-IN-10 (0.156 mM-10 mM; injected into the eggs) showed good protection against both H5N1 and H5N8 strains in a dose-dependent manner in a chicken embryonated egg model .Animal Model:SPF Chicken Embryonated Egg
Dosage:0.156 mM; 0.625 mM; 2.5 mM; 10 mM
Administration:Injected into the egg
Result:were not as effective as OSC in this infection model, but also exhibited a certain therapeutic effect.The survival rates of?Neuraminidase-IN-10?(H5N1: 100 and 40%, respectively; H5N8: 100 and 100%, respectively)? at 2.5 mM and 10 mM.
体外研究：
Neuraminidase-IN-10 displays promising anti-influenza virus activity with EC50 value of 7.28 and 0.71μM for H5N1 and H5N8, respectively in CEFs. Neuraminidase-IN-10 displays anti-influenza virus activity with EC50 values of 0.04?±?0.04 and 28.70?±?1.61 μM, respectively in MDCK Cells.Metabolic stability is an important indicator for the assessment of drug candidates. Neuraminidase-IN-10 exhibits a T1/2?(min), CLint(mic) (μL/min/kg), CLint (liver) (mL/min/kg) and remaining (T=60?min)(%) values of 120.5 min, 11.5 μL/min/kg, 10.4 mL/min/kg and 73.8 mins, respectively.
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