产品
编 号：F754608
分子式：C32H27BrO10
分子量：651.45
分子式：C32H27BrO10
分子量：651.45
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
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询价
结构图
CAS No: 2684412-41-5
产品详情
生物活性：
PI3K/AKT-IN-2 (Compound 12c) is a PI3K and AKT inhibitor. PI3K/AKT-IN-2 blocks the epithelial-mesenchymal transition (EMT) and induces apoptosis. PI3K/AKT-IN-2 inhibits the polymerization of tubulin.
体外研究：
PI3K/AKT-IN-2 (Compound 12c) shows antiproliferative activity with IC50 values of 14.84 ± 1.53, 4.79 ± 0.71, 14.34 ± 0.57, 0.89 ± 0.023, >100 and 98.75 ± 1.59 μM against H460, MCF-7, A549, HGC-27, 293 T and GES-1 cells, respectively.PI3K/AKT-IN-2 suppresses the expressions/activities of matrix metalloprotease (MMP)? 2, vimentin and up-regulation E-cadherin.PI3K/AKT-IN-2 induces significant up-regulation of CDK1 proteins expression with a down-regulation of cyclin B1 and Cdc25C.
PI3K/AKT-IN-2 (Compound 12c) is a PI3K and AKT inhibitor. PI3K/AKT-IN-2 blocks the epithelial-mesenchymal transition (EMT) and induces apoptosis. PI3K/AKT-IN-2 inhibits the polymerization of tubulin.
体外研究：
PI3K/AKT-IN-2 (Compound 12c) shows antiproliferative activity with IC50 values of 14.84 ± 1.53, 4.79 ± 0.71, 14.34 ± 0.57, 0.89 ± 0.023, >100 and 98.75 ± 1.59 μM against H460, MCF-7, A549, HGC-27, 293 T and GES-1 cells, respectively.PI3K/AKT-IN-2 suppresses the expressions/activities of matrix metalloprotease (MMP)? 2, vimentin and up-regulation E-cadherin.PI3K/AKT-IN-2 induces significant up-regulation of CDK1 proteins expression with a down-regulation of cyclin B1 and Cdc25C.
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