产品
编 号：F754568
分子式：C77H116Gd2N14O22S2
分子量：1968.46
分子式：C77H116Gd2N14O22S2
分子量：1968.46
产品类型
规格
价格
是否有货
结构图
CAS No: 2678579-76-3
产品详情
生物活性：
Gd-NMC-3 is a near-infrared fluorescence/magnetic resonance (NIRF/MR) bimodal imaging probe. Gd-NMC-3 shows high resolution and sensitivity in tumor imaging with good biocompatibility, indicating huge application potential.
体内研究：
Gd-NMC-3 (20 mg/kg; i.v.) holds an excellent tumor targeting ability, shows high resolution and sensitivity and provides real-time visual navigation in LM3 orthotopic and subcutaneous tumor models to guide the resection of tumors.Animal Model:HepG2 subcutaneous xenograft mice
Dosage:20 mg/kg
Administration:Intravenous injection; 1.5 h later dissected tumors
Result:Accumulated in the tumor after injection and produced stronger fluorescence intensity in tumor tissues.Remained fluorescence signal longer than 1.5 h, and provided high-resolution images of the tumor tissues with a SNR of 4.32.
Animal Model:LM3 orthotopic mice
Dosage:20 mg/kg
Administration:Intravenous injection
Result:Decreased gradually the fluorescence intensity in LM3 orthotopic liver tumors after administration, whereas tumor-to-skin fluorescence ratios increased due to high accumulation and low clearance in tumor tissues.
体外研究：
Gd-NMC-3 shows the maximum excitation wavelength and emission wavelength are 755 and 792 nm, respectively. Both wavelengths are located in the near-infrared region.Gd-NMC-3 acts as a bimodal imaging molecule, can be accumulated in tumor sites.Gd-NMC-3 (50 μM; 24 h) can be internalized into cancer cells by OATPs and NTCP, indicating an excellent specificity to tumor tissues.Gd-NMC-3 (6.25-800 μM, 24 h) exhibits significant fluorescence accumulation (with the optimal concentration of 100, 200 μM) and reasonable relaxation property (11.64 M/m/s) in tumors.Gd-NMC-3 (6.25-100 μM, 48 h) displays low cytotoxicity and good biocompatibility.
Gd-NMC-3 is a near-infrared fluorescence/magnetic resonance (NIRF/MR) bimodal imaging probe. Gd-NMC-3 shows high resolution and sensitivity in tumor imaging with good biocompatibility, indicating huge application potential.
体内研究：
Gd-NMC-3 (20 mg/kg; i.v.) holds an excellent tumor targeting ability, shows high resolution and sensitivity and provides real-time visual navigation in LM3 orthotopic and subcutaneous tumor models to guide the resection of tumors.Animal Model:HepG2 subcutaneous xenograft mice
Dosage:20 mg/kg
Administration:Intravenous injection; 1.5 h later dissected tumors
Result:Accumulated in the tumor after injection and produced stronger fluorescence intensity in tumor tissues.Remained fluorescence signal longer than 1.5 h, and provided high-resolution images of the tumor tissues with a SNR of 4.32.
Animal Model:LM3 orthotopic mice
Dosage:20 mg/kg
Administration:Intravenous injection
Result:Decreased gradually the fluorescence intensity in LM3 orthotopic liver tumors after administration, whereas tumor-to-skin fluorescence ratios increased due to high accumulation and low clearance in tumor tissues.
体外研究：
Gd-NMC-3 shows the maximum excitation wavelength and emission wavelength are 755 and 792 nm, respectively. Both wavelengths are located in the near-infrared region.Gd-NMC-3 acts as a bimodal imaging molecule, can be accumulated in tumor sites.Gd-NMC-3 (50 μM; 24 h) can be internalized into cancer cells by OATPs and NTCP, indicating an excellent specificity to tumor tissues.Gd-NMC-3 (6.25-800 μM, 24 h) exhibits significant fluorescence accumulation (with the optimal concentration of 100, 200 μM) and reasonable relaxation property (11.64 M/m/s) in tumors.Gd-NMC-3 (6.25-100 μM, 48 h) displays low cytotoxicity and good biocompatibility.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备