产品
编 号：F754544
分子式：C46H44F2N8
分子量：746.89
分子式：C46H44F2N8
分子量：746.89
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规格
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结构图
CAS No: 2675490-72-7
产品详情
生物活性：
DIZ-3 is a selective multimeric G4 ligand based on a G4-ligand-dimerizing strategy. DIZ-3 intercalates into the G4-G4 interface, stabilizing the higher-order structure. DIZ-3 induces cell cycle arrest and apoptosis, and thus inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cells.
体外研究：
DIZ-3 (0-40 μM; 24 小时) 抑制 ALT 癌细胞系的增殖。 DIZ-3 (0.6-2.5 μM; 24小时) 诱导 U2OS 细胞周期停滞和细胞凋亡。 DIZ-3 (0.12, 0.25, 0.5 μM; 7 天) 导致 U2OS 细胞集落形成。 DIZ-3 (0.12, 0.25, 0.5 μM; 24小时) 显着抑制 U2OS 细胞的迁移。
DIZ-3 is a selective multimeric G4 ligand based on a G4-ligand-dimerizing strategy. DIZ-3 intercalates into the G4-G4 interface, stabilizing the higher-order structure. DIZ-3 induces cell cycle arrest and apoptosis, and thus inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cells.
体外研究：
DIZ-3 (0-40 μM; 24 小时) 抑制 ALT 癌细胞系的增殖。 DIZ-3 (0.6-2.5 μM; 24小时) 诱导 U2OS 细胞周期停滞和细胞凋亡。 DIZ-3 (0.12, 0.25, 0.5 μM; 7 天) 导致 U2OS 细胞集落形成。 DIZ-3 (0.12, 0.25, 0.5 μM; 24小时) 显着抑制 U2OS 细胞的迁移。
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