产品
编 号：F754489
分子式：C32H29ClN8O5
分子量：641.08
分子式：C32H29ClN8O5
分子量：641.08
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 2669072-88-0
产品详情
生物活性：
PROTAC HSP90 degrader BP3 is a potent and selective degradation of HSP90 in a CRBN-dependent fashion. PROTAC HSP90 degrader BP3 has a certain degradation effect on HSP90 protein in MCF-7 cells (DC50=0.99 μM). PROTAC HSP90 degrader BP3 inhibits the growth of breast cancer cell. PROTAC HSP90 degrader BP3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
PROTAC HSP90 degrader BP3 (40 mg/kg; i.p., daily for 12 days) inhibits tumor growth and the tumor inhibition rate is 76.41%.Animal Model:6- to 8-week-old female BALB/c mice
Dosage:40 mg/kg
Administration:i.p., daily, 12 days
Result:Inhibited tumor growth and the tumor inhibition rate was 76.41%.
体外研究：
PROTAC HSP90 degrader BP3 (compound 16b) (72 h) inhibits the growth of breast cancer cells (IC50=0.63 μM in MCF-7 cells, IC50=3.53 μM in MDA-MB-231 cells, IC50=0.61 μM in 4T1 cells, IC50=2.95 μM in MDA-MB-468 cells).PROTAC HSP90 degrader BP3 (2 μM; 6 h) shows degradation activity in the MCF-7 cells (DC50=0.99 μM).
PROTAC HSP90 degrader BP3 is a potent and selective degradation of HSP90 in a CRBN-dependent fashion. PROTAC HSP90 degrader BP3 has a certain degradation effect on HSP90 protein in MCF-7 cells (DC50=0.99 μM). PROTAC HSP90 degrader BP3 inhibits the growth of breast cancer cell. PROTAC HSP90 degrader BP3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
PROTAC HSP90 degrader BP3 (40 mg/kg; i.p., daily for 12 days) inhibits tumor growth and the tumor inhibition rate is 76.41%.Animal Model:6- to 8-week-old female BALB/c mice
Dosage:40 mg/kg
Administration:i.p., daily, 12 days
Result:Inhibited tumor growth and the tumor inhibition rate was 76.41%.
体外研究：
PROTAC HSP90 degrader BP3 (compound 16b) (72 h) inhibits the growth of breast cancer cells (IC50=0.63 μM in MCF-7 cells, IC50=3.53 μM in MDA-MB-231 cells, IC50=0.61 μM in 4T1 cells, IC50=2.95 μM in MDA-MB-468 cells).PROTAC HSP90 degrader BP3 (2 μM; 6 h) shows degradation activity in the MCF-7 cells (DC50=0.99 μM).
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