产品
编 号：F754479
分子式：C24H27N9O
分子量：457.53
分子式：C24H27N9O
分子量：457.53
产品类型
规格
价格
是否有货
结构图
CAS No: 2667681-57-2
产品详情
生物活性：
IRAK4-IN-13 (compound 21) is a potent and selective IRAK4 inhibitor with an IC50 of 0.6 nM. IRAK4-IN-13 shows high metabolic clearance with human liver microsomes (HLM) intrinsic clearance is 96 μL/min/mg.
体外研究：
IRAK4-IN-13 (compound 21) shows cell pIRAK4 potencies with an IC50 of 0.024 μM.IRAK4-IN-13 (compound 21) shows selectivity with IC50s of 0.0006, 0.002, 0.044, 1.2, 0.018, 0.019, 0.082, 0.036 μM for IRAK4, IRAK1, BTK, Flt3, PI3Kδ, TRKa, TRKb, TRKc, respectively.
IRAK4-IN-13 (compound 21) is a potent and selective IRAK4 inhibitor with an IC50 of 0.6 nM. IRAK4-IN-13 shows high metabolic clearance with human liver microsomes (HLM) intrinsic clearance is 96 μL/min/mg.
体外研究：
IRAK4-IN-13 (compound 21) shows cell pIRAK4 potencies with an IC50 of 0.024 μM.IRAK4-IN-13 (compound 21) shows selectivity with IC50s of 0.0006, 0.002, 0.044, 1.2, 0.018, 0.019, 0.082, 0.036 μM for IRAK4, IRAK1, BTK, Flt3, PI3Kδ, TRKa, TRKb, TRKc, respectively.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备