产品
编 号：F754441
分子式：C28H29ClN4O4
分子量：521.01
分子式：C28H29ClN4O4
分子量：521.01
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CAS No: 2658488-68-5
产品详情
生物活性：
FGFR-IN-11 (compound I-5) is an orally active and covalent FGFR inhibitor with IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4), respectively. FGFR-IN-11 inhibits multiple cancer cell proliferation with nanomolar activity. FGFR-IN-11 inhibits tumor growth significantly in xenograft mice models.
体内研究：
FGFR-IN-11 (60 mg/kg， 口服， 每天一次， 21 天) 在雌性裸鼠的 Huh-7 或 NCI-H1581 异种移植瘤模型中显著抑制肿瘤生长并且不影响小鼠体重。Animal Model:Huh-7 xenograft model in female nude mice
Dosage:15, 30, 60 mg/kg
Administration:Oral administration (p.o.)
Result:Inhibited tumor growth of 88.2% at the dose of 60 mg/kg and had no significant changes in body weight.
Animal Model:NCI-H1581 xenograft model in female nude mice
Dosage:60 mg/kg
Administration:Oral administration (p.o.)
Result:Inhibited tumor growth of 67% and had no significant changes in body weight.
体外研究：
FGFR-IN-11 (0.3 nM-20 μM， 72 h) 以纳摩尔活性抑制多种癌细胞生长。
FGFR-IN-11 (compound I-5) is an orally active and covalent FGFR inhibitor with IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4), respectively. FGFR-IN-11 inhibits multiple cancer cell proliferation with nanomolar activity. FGFR-IN-11 inhibits tumor growth significantly in xenograft mice models.
体内研究：
FGFR-IN-11 (60 mg/kg， 口服， 每天一次， 21 天) 在雌性裸鼠的 Huh-7 或 NCI-H1581 异种移植瘤模型中显著抑制肿瘤生长并且不影响小鼠体重。Animal Model:Huh-7 xenograft model in female nude mice
Dosage:15, 30, 60 mg/kg
Administration:Oral administration (p.o.)
Result:Inhibited tumor growth of 88.2% at the dose of 60 mg/kg and had no significant changes in body weight.
Animal Model:NCI-H1581 xenograft model in female nude mice
Dosage:60 mg/kg
Administration:Oral administration (p.o.)
Result:Inhibited tumor growth of 67% and had no significant changes in body weight.
体外研究：
FGFR-IN-11 (0.3 nM-20 μM， 72 h) 以纳摩尔活性抑制多种癌细胞生长。
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