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编 号:F754411
分子式:C53H61N7O11
分子量:972.09
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生物活性:
CypD-IN-3 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-3 has CypD affinity with an IC50 value of 0.01 μM. CypD-IN-3 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes.

体外研究:
CypD-IN-3 (B52) has selectivity for inhibiting CypD, CypA, CypB and CypE with IC50 values of 0.01 μM, 1.1 μM, 0.21 μM and 0.31 μM, respectively.CypD-IN-3 (10 μM) inhibits mitochondrial permeability transition pore opening in isolated mitochondria.
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