产品
编 号：F754403
分子式：C21H23F2N3O4
分子量：419.42
分子式：C21H23F2N3O4
分子量：419.42
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CAS No: 2650640-17-6
产品详情
生物活性：
CDK9-IN-14 is a potent and selective CDK9 inhibitor with IC50 of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and has a good selectivity and a low toxicity and few side effects.
体内研究：
CDK9-IN-14 (5 mg/kg; p.o., qd, for 9 days) exhibits significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%.Animal Model:Female Nu/Nu mice (6-8 weeks old, 18-22 g, injected with HL-60 cells)
Dosage:5 mg/kg
Administration:p.o., qd, for 9 days
Result:Exhibited significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%.
体外研究：
CDK9-IN-14 (0-1000 nM) has strong inhibitory effect in MV4;11 cells with IC50 = 34 nM.
CDK9-IN-14 is a potent and selective CDK9 inhibitor with IC50 of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and has a good selectivity and a low toxicity and few side effects.
体内研究：
CDK9-IN-14 (5 mg/kg; p.o., qd, for 9 days) exhibits significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%.Animal Model:Female Nu/Nu mice (6-8 weeks old, 18-22 g, injected with HL-60 cells)
Dosage:5 mg/kg
Administration:p.o., qd, for 9 days
Result:Exhibited significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%.
体外研究：
CDK9-IN-14 (0-1000 nM) has strong inhibitory effect in MV4;11 cells with IC50 = 34 nM.
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