产品
编 号：F754395
分子式：C19H17NO4
分子量：323.34
分子式：C19H17NO4
分子量：323.34
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2650074-56-7
产品详情
生物活性：
Seconeolitsine, an antibiotic, and is an inhibitor of targeting topoisomerase I (TopA). Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC50 value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics.
体内研究：
Seconeolitsine (compounds 17) increases supercoiling and TopA is target in vivo.
体外研究：
Seconeolitsine (compounds 17) inhibits TopA relaxation activity in a concentration-dependent manner, with an IC50 value of 17 μM and the inhibition of TopAis enhanced by preincubation of the enzyme with the alkaloid.Seconeolitsine shows great inhibition of S.pneumoniae growth with MIC50 values of 16 μM for R6, ATCC6303, CipS8, CipS9, CipR20, CipR16, CipR8, CipR45 and CipR5. And shows great inhibition of S. pneumoniae growth with MIC50 values of 8 μM for CipR42, CipR68 and CipR15.Seconeolitsine has activation at low concentrations and partial inhibition at 50 μM, a concentration at which the pneumococcal TopA showed full inhibition, but not inhibits Human TOPO1.Seconeolitsine (0.25×-1×MIC) affects cell growth and division in a concentration-dependent manner.Seconeolitsine (30 and 100 μM), is not affected neutrophil apoptosis and human cell viability.
Seconeolitsine, an antibiotic, and is an inhibitor of targeting topoisomerase I (TopA). Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC50 value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics.
体内研究：
Seconeolitsine (compounds 17) increases supercoiling and TopA is target in vivo.
体外研究：
Seconeolitsine (compounds 17) inhibits TopA relaxation activity in a concentration-dependent manner, with an IC50 value of 17 μM and the inhibition of TopAis enhanced by preincubation of the enzyme with the alkaloid.Seconeolitsine shows great inhibition of S.pneumoniae growth with MIC50 values of 16 μM for R6, ATCC6303, CipS8, CipS9, CipR20, CipR16, CipR8, CipR45 and CipR5. And shows great inhibition of S. pneumoniae growth with MIC50 values of 8 μM for CipR42, CipR68 and CipR15.Seconeolitsine has activation at low concentrations and partial inhibition at 50 μM, a concentration at which the pneumococcal TopA showed full inhibition, but not inhibits Human TOPO1.Seconeolitsine (0.25×-1×MIC) affects cell growth and division in a concentration-dependent manner.Seconeolitsine (30 and 100 μM), is not affected neutrophil apoptosis and human cell viability.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备