产品
编 号：F754394
分子式：C27H30N4O2S
分子量：474.62
分子式：C27H30N4O2S
分子量：474.62
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CAS No: 2649904-85-6
产品详情
生物活性：
SMCypI C31 is a non-peptidic cyclophilin inhibitor with potent peptidyl-prolyl cis/trans isomerases (PPIase) inhibitory activity (IC50 of 0.1 μM). SMCypI C31 shows pangenotype anti-HCV activity with EC50s ranging from 1.20 to 7.76 μM for genotype 1a, 1b, 2a, 3a, and 5a HCV subgenomic replicons (HCV-SGRs) and chimeric genotype 2a/4a HCV-SGRs. SMCypI C31 disrupts the cyclophilin A-NS5A interaction.
体外研究：
SMCypI C31 (C31) inhibited the replication of genotype 1a, 1b, 2a, 3a, and 5a HCV-SGRs and chimeric genotype 2a/4a HCV-SGRs, with EC50 values of3.80 μM, 2.95 μM, 2.30 μM, 7.76 μM, 1.20 μM and 1.40 μM, respectively.SMCypI C31 also inhibits the replication of the infectious J6/JFH1 virus, with an EC50 of 2.80 μM. SMCypI C31 inhibits DBN-3acc RNA replication in a dose-dependent manner, with a maximal 244-fold HCV RNA reduction at 10 μM.SMCypI C31 (C31) inhibits the replication of other members of the Flaviviridae family. SMCypI C31 inhibits viral replication of DENV (EC50 of 7.3 μM), YFV (EC50 of 27.2 μM), and ZIKV (EC50 of 48.0 μM).
SMCypI C31 is a non-peptidic cyclophilin inhibitor with potent peptidyl-prolyl cis/trans isomerases (PPIase) inhibitory activity (IC50 of 0.1 μM). SMCypI C31 shows pangenotype anti-HCV activity with EC50s ranging from 1.20 to 7.76 μM for genotype 1a, 1b, 2a, 3a, and 5a HCV subgenomic replicons (HCV-SGRs) and chimeric genotype 2a/4a HCV-SGRs. SMCypI C31 disrupts the cyclophilin A-NS5A interaction.
体外研究：
SMCypI C31 (C31) inhibited the replication of genotype 1a, 1b, 2a, 3a, and 5a HCV-SGRs and chimeric genotype 2a/4a HCV-SGRs, with EC50 values of3.80 μM, 2.95 μM, 2.30 μM, 7.76 μM, 1.20 μM and 1.40 μM, respectively.SMCypI C31 also inhibits the replication of the infectious J6/JFH1 virus, with an EC50 of 2.80 μM. SMCypI C31 inhibits DBN-3acc RNA replication in a dose-dependent manner, with a maximal 244-fold HCV RNA reduction at 10 μM.SMCypI C31 (C31) inhibits the replication of other members of the Flaviviridae family. SMCypI C31 inhibits viral replication of DENV (EC50 of 7.3 μM), YFV (EC50 of 27.2 μM), and ZIKV (EC50 of 48.0 μM).
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