产品
编 号：F754368
分子式：C30H25ClN4O7
分子量：589
分子式：C30H25ClN4O7
分子量：589
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2649154-57-2
产品详情
生物活性：
RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead.
体内研究：
RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice.Animal Model:RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice.
Dosage:10 mg/kg.
Administration:IP for a 5 days on, 2 days off cycle for two weeks.
Result:Reduced ovarian tumor burden in mice.
Animal Model:Female Balb/c mice.
Dosage:5, 10, 20, 40, 60, 100 mg/kg (Pharmacological Analysis).
Administration:IP single dose.
Result:The dose of 40 mg/kg on alternate days for two weeks produced no observable toxicities or weight loss.
RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead.
体内研究：
RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice.Animal Model:RA375 (10 mg/kg, ip) inhibits proteasome function and reduces ovarian tumor burden in mice.
Dosage:10 mg/kg.
Administration:IP for a 5 days on, 2 days off cycle for two weeks.
Result:Reduced ovarian tumor burden in mice.
Animal Model:Female Balb/c mice.
Dosage:5, 10, 20, 40, 60, 100 mg/kg (Pharmacological Analysis).
Administration:IP single dose.
Result:The dose of 40 mg/kg on alternate days for two weeks produced no observable toxicities or weight loss.
产品资料
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