产品
编 号：F754366
分子式：C18H18ClN5O3
分子量：387.82
分子式：C18H18ClN5O3
分子量：387.82
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CAS No: 2649120-20-5
产品详情
生物活性：
CDK4/6-IN-7 is a potent, selective and orally active CDK4/6 inhibitor, with IC50s of 1.58 and 4.09 nM, respectively. CDK4/6-IN-7 can be used for the research of breast cancer.
体内研究：
CDK4/6-IN-7 (compound 7c) (50 mg/kg; p.o. once daily for 7d) strongly reduces tumor growth rates in MCF-7 tumor-bearing mice.Animal Model:Female nude mice (5 weeks) bearing MCF-7 tumor
Dosage:50 mg/kg
Administration:Oral gavage once daily for 7 days
Result:Inhibited tumor growth with the tumor inhibition rate of 57.68% and was well tolerated.
体外研究：
CDK4/6-IN-7 (compound 7c) (0.1-656.1 μM; 48 h) inhibits the viability of MCF-7 cells, with an IC50 of 0.92 μM.
CDK4/6-IN-7 is a potent, selective and orally active CDK4/6 inhibitor, with IC50s of 1.58 and 4.09 nM, respectively. CDK4/6-IN-7 can be used for the research of breast cancer.
体内研究：
CDK4/6-IN-7 (compound 7c) (50 mg/kg; p.o. once daily for 7d) strongly reduces tumor growth rates in MCF-7 tumor-bearing mice.Animal Model:Female nude mice (5 weeks) bearing MCF-7 tumor
Dosage:50 mg/kg
Administration:Oral gavage once daily for 7 days
Result:Inhibited tumor growth with the tumor inhibition rate of 57.68% and was well tolerated.
体外研究：
CDK4/6-IN-7 (compound 7c) (0.1-656.1 μM; 48 h) inhibits the viability of MCF-7 cells, with an IC50 of 0.92 μM.
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