产品
编 号：F754323
分子式：C36H44BrN10O2P
分子量：759.68
分子式：C36H44BrN10O2P
分子量：759.68
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规格
价格
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结构图
CAS No: 2648206-31-7
产品详情
生物活性：
EGFR-IN-21 is a potent EGFR inhibtior with an IC50 of 0.38 nM. EGFR-IN-21 has antitumor activity.
体内研究：
EGFR-IN-21 (1 mg/kg; IV) has a T1/2 of 3.33 hours, and a Vss of 0.374 L/kg for female CD-1 mouse. EGFR-IN-21 (5 mg/kg;po) has a T1/2 of 3.13 hours, a Cmax of 2077 ng/ml and an AUC of 7542 h·ng/ml.
体外研究：
EGFR-IN-21 inhibits HEK293T cells (IC50=951.51 nM) and PC9 EGFR-Del19/T790M/C797S cells (IC50=135.11 nM).
EGFR-IN-21 is a potent EGFR inhibtior with an IC50 of 0.38 nM. EGFR-IN-21 has antitumor activity.
体内研究：
EGFR-IN-21 (1 mg/kg; IV) has a T1/2 of 3.33 hours, and a Vss of 0.374 L/kg for female CD-1 mouse. EGFR-IN-21 (5 mg/kg;po) has a T1/2 of 3.13 hours, a Cmax of 2077 ng/ml and an AUC of 7542 h·ng/ml.
体外研究：
EGFR-IN-21 inhibits HEK293T cells (IC50=951.51 nM) and PC9 EGFR-Del19/T790M/C797S cells (IC50=135.11 nM).
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