产品
编 号：F754289
分子式：C25H21Cl2N3O8
分子量：562.36
分子式：C25H21Cl2N3O8
分子量：562.36
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规格
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结构图
CAS No: 264275-77-6
产品详情
生物活性：
XVA143, an α/β I-like allosteric antagonist, inhibits LFA-1 dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and in vivo.
体外研究：
XVA143 (1 μM) completely abolishes binding of ICAM-1 to LFA-1 in Mn2+ and Mg2+/EGTA, with no hint of agonism.XVA143 restores rolling of the αL-E310A β2 mutant by inducing extension of αL.
XVA143, an α/β I-like allosteric antagonist, inhibits LFA-1 dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and in vivo.
体外研究：
XVA143 (1 μM) completely abolishes binding of ICAM-1 to LFA-1 in Mn2+ and Mg2+/EGTA, with no hint of agonism.XVA143 restores rolling of the αL-E310A β2 mutant by inducing extension of αL.
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