产品
编 号：F754138
分子式：C16H18N6O3S
分子量：374.42
分子式：C16H18N6O3S
分子量：374.42
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2631703-41-6
产品详情
生物活性：
Enpp-1-IN-12 (compound 43) is a potent and orally active ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor, with a Ki of 41 nM. Enpp-1-IN-12 exhibits anti-tumor activity.
体内研究：
Enpp-1-IN-12 (100 mg/kg; p.o.) inhibits tumor growth in LLC1 syngeneic murine tumor model for lung cancer.Enpp-1-IN-12 (10 mg/kg; p.o.) exhibits moderate oral bioavailability (F=45.1%), half-life (t1/2=1.04 h), and Cmax (303.10 ng/mL) in healthy female BALB/c mice.Enpp-1-IN-12 (1 mg/kg; i.v.) exhibits half-life (t1/2=0.76 h), Cmax (308.64 ng/mL), and CL of 73.22 mL/min/kg in healthy female BALB/c mice.
体外研究：
Enpp-1-IN-12 (5 μM) exhibits half-life and intrinsic clearance of >120 min and Enpp-1-IN-12 相关抗体:
Enpp-1-IN-12 (compound 43) is a potent and orally active ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor, with a Ki of 41 nM. Enpp-1-IN-12 exhibits anti-tumor activity.
体内研究：
Enpp-1-IN-12 (100 mg/kg; p.o.) inhibits tumor growth in LLC1 syngeneic murine tumor model for lung cancer.Enpp-1-IN-12 (10 mg/kg; p.o.) exhibits moderate oral bioavailability (F=45.1%), half-life (t1/2=1.04 h), and Cmax (303.10 ng/mL) in healthy female BALB/c mice.Enpp-1-IN-12 (1 mg/kg; i.v.) exhibits half-life (t1/2=0.76 h), Cmax (308.64 ng/mL), and CL of 73.22 mL/min/kg in healthy female BALB/c mice.
体外研究：
Enpp-1-IN-12 (5 μM) exhibits half-life and intrinsic clearance of >120 min and Enpp-1-IN-12 相关抗体:
产品资料
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