产品
编 号：F754125
分子式：C31H34F2N4O18
分子量：788.61
分子式：C31H34F2N4O18
分子量：788.61
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 2629250-69-5
产品详情
生物活性：
SSK1, a senescence-specific killing compound, is a β-galactosidase-targeted proagent attenuates inflammation. SSK1 is activated by lysosomal β-galactosidase and selectively killed senescent cells through the activation of p38 MAPK and induction of apoptosis.
体内研究：
SSK1 (0.5 mg/kg；腹腔注射；每周两天；持续 4 周) 可消除肺损伤小鼠的衰老细胞并降低衰老相关标记物。小鼠 (20 个月大)，SSK1 (0.5 mg/kg；每 2 周 3 天，持续 8 周) 有效清除不同组织中的衰老细胞，减少衰老和年龄相关基因特征，减弱低级别局部和全身炎症，恢复身体机能。Animal Model:Mice (3-6-month-old) were subjected to transtracheal injection of Bleomycin
Dosage:0.5 mg/kg
Administration:Intraperitoneally injection; two days every week; for four weeks
Result:SSK1 significantly reduced the percentage of SA-β-gal-positive cells in lung by 3.8-fold compared with that in vehicle-treated lung-injured mice
体外研究：
SSK1 (0.5 μM；12-72 小时) 激活衰老细胞中 p38 MAPK 和 MKK3/MKK6 的磷酸化水平。SSK1 通过激活 p38 MAPK 信号通路杀死衰老细胞。SSK1 能够在衰老细胞中诱导线粒体 DNA 损伤。 SSK1 (0.01-1 μM；3 天) 选择性并有效地消除广泛范围内的 β-半乳糖苷酶阳性衰老细胞处理窗。
SSK1, a senescence-specific killing compound, is a β-galactosidase-targeted proagent attenuates inflammation. SSK1 is activated by lysosomal β-galactosidase and selectively killed senescent cells through the activation of p38 MAPK and induction of apoptosis.
体内研究：
SSK1 (0.5 mg/kg；腹腔注射；每周两天；持续 4 周) 可消除肺损伤小鼠的衰老细胞并降低衰老相关标记物。小鼠 (20 个月大)，SSK1 (0.5 mg/kg；每 2 周 3 天，持续 8 周) 有效清除不同组织中的衰老细胞，减少衰老和年龄相关基因特征，减弱低级别局部和全身炎症，恢复身体机能。Animal Model:Mice (3-6-month-old) were subjected to transtracheal injection of Bleomycin
Dosage:0.5 mg/kg
Administration:Intraperitoneally injection; two days every week; for four weeks
Result:SSK1 significantly reduced the percentage of SA-β-gal-positive cells in lung by 3.8-fold compared with that in vehicle-treated lung-injured mice
体外研究：
SSK1 (0.5 μM；12-72 小时) 激活衰老细胞中 p38 MAPK 和 MKK3/MKK6 的磷酸化水平。SSK1 通过激活 p38 MAPK 信号通路杀死衰老细胞。SSK1 能够在衰老细胞中诱导线粒体 DNA 损伤。 SSK1 (0.01-1 μM；3 天) 选择性并有效地消除广泛范围内的 β-半乳糖苷酶阳性衰老细胞处理窗。
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