产品
编 号：F754061
分子式：C17H8F9N3O
分子量：441.25
分子式：C17H8F9N3O
分子量：441.25
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CAS No: 2615254-55-0
产品详情
生物活性：
Antibacterial agent 123 (compound 111) is a potent membrane-disrupting agent to combat antibiotic-resistant Gram-positive bacteria.
体内研究：
Antibacterial agent 123 (compound 111) (p.o. (10 mg/kg) and i.v. (0.5 mg/kg); once) exhibits favorable pharmacokinetics profiles.Animal Model:Female CD-1 mice
Dosage:0.5 mg/kg, 10 mg/kg
Administration:p.o. (10 mg/kg) and i.v. (0.5 mg/kg); once (Pharmacokinetic Analysis)
Result:Pharmacokinetic Parameters of Antibacterial agent 123 in Female CD-1 Mice.pharmacokinetic indicesdose i.v., p.o. (mg/kg) AUC0-24 (i.v., h·ng/mL)Vd (i.v., mL/kg) CL (i.v., mL/(kg·h)) t1/2 (i.v., h) AUC0-24 (p.o., h·ng/mL)Cmax (p.o., ng/mL) F (%)
compound 1110.5, 10(4.20 × 103) ± 308322 ± 24119 ± 9.21.88 ± 0.08(4.33 × 104) ± 543(3.10 × 103) ± 78051.6 ± 5.2
体外研究：
Antibacterial agent 123 (compound 111) shows excellent activity (MICAntibacterial agent 123 相关抗体:
Antibacterial agent 123 (compound 111) is a potent membrane-disrupting agent to combat antibiotic-resistant Gram-positive bacteria.
体内研究：
Antibacterial agent 123 (compound 111) (p.o. (10 mg/kg) and i.v. (0.5 mg/kg); once) exhibits favorable pharmacokinetics profiles.Animal Model:Female CD-1 mice
Dosage:0.5 mg/kg, 10 mg/kg
Administration:p.o. (10 mg/kg) and i.v. (0.5 mg/kg); once (Pharmacokinetic Analysis)
Result:Pharmacokinetic Parameters of Antibacterial agent 123 in Female CD-1 Mice.pharmacokinetic indicesdose i.v., p.o. (mg/kg) AUC0-24 (i.v., h·ng/mL)Vd (i.v., mL/kg) CL (i.v., mL/(kg·h)) t1/2 (i.v., h) AUC0-24 (p.o., h·ng/mL)Cmax (p.o., ng/mL) F (%)
compound 1110.5, 10(4.20 × 103) ± 308322 ± 24119 ± 9.21.88 ± 0.08(4.33 × 104) ± 543(3.10 × 103) ± 78051.6 ± 5.2
体外研究：
Antibacterial agent 123 (compound 111) shows excellent activity (MICAntibacterial agent 123 相关抗体:
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