产品
编 号：F754021
分子式：C31H22N2O2
分子量：454.52
分子式：C31H22N2O2
分子量：454.52
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
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25mg
询价
询价
50mg
询价
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100mg
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询价
结构图
CAS No: 2601734-99-8
产品详情
生物活性：
SIRT6 activator 12q is potent, selective and orally active SIRT6 activator with IC50 values of 171.20, >200, >200, >200, 0.58 μM for SIRT1, SIRT2, SIRT3, SIRT5, SIRT6, respectively. SIRT6 activator 12q inhibits cell growth and migration. SIRT6 activator 12q induces Apoptosis and cell cycle arrest at G2 phase. SIRT6 activator 12q shows anticancer activity.
体内研究：
SIRT6 activator 12q (100, 150 mg/kg; p.o.; daily for 30 days) 以剂量依赖性方式抑制小鼠肿瘤生长。Animal Model:BALB/c female nude mice (human pancreatic tumor xenograft model of PANC-1)
Dosage:100, 150 mg/kg
Administration:P.o.; daily for 30 days
Result:Inhibited tumer growth in a dose-dependent manner, and a tumor inhibition rate of 90.25% at a dose of 150 mg/kg.
体外研究：
SIRT6 activator 12q (2.5, 5, 10 μM; 14, 18 days) 以剂量依赖性方式抑制 PANC-1、BXPC-3、MIAPaCa-2 和 AsPC-1 细胞的集落形成 .SIRT6 activator 12q (10, 25, 50 μM; 48 h) 以剂量依赖性方式诱导细胞凋亡和细胞周期停滞在 G2 期。SIRT6 activator 12q (12.5, 25, 50 μM; 48 h) 以剂量依赖性方式降低 PANC-1 和 BXPC-3 细胞中 H3K9ac、H3K18ac 和 H3K56ac 的蛋白表达。
SIRT6 activator 12q is potent, selective and orally active SIRT6 activator with IC50 values of 171.20, >200, >200, >200, 0.58 μM for SIRT1, SIRT2, SIRT3, SIRT5, SIRT6, respectively. SIRT6 activator 12q inhibits cell growth and migration. SIRT6 activator 12q induces Apoptosis and cell cycle arrest at G2 phase. SIRT6 activator 12q shows anticancer activity.
体内研究：
SIRT6 activator 12q (100, 150 mg/kg; p.o.; daily for 30 days) 以剂量依赖性方式抑制小鼠肿瘤生长。Animal Model:BALB/c female nude mice (human pancreatic tumor xenograft model of PANC-1)
Dosage:100, 150 mg/kg
Administration:P.o.; daily for 30 days
Result:Inhibited tumer growth in a dose-dependent manner, and a tumor inhibition rate of 90.25% at a dose of 150 mg/kg.
体外研究：
SIRT6 activator 12q (2.5, 5, 10 μM; 14, 18 days) 以剂量依赖性方式抑制 PANC-1、BXPC-3、MIAPaCa-2 和 AsPC-1 细胞的集落形成 .SIRT6 activator 12q (10, 25, 50 μM; 48 h) 以剂量依赖性方式诱导细胞凋亡和细胞周期停滞在 G2 期。SIRT6 activator 12q (12.5, 25, 50 μM; 48 h) 以剂量依赖性方式降低 PANC-1 和 BXPC-3 细胞中 H3K9ac、H3K18ac 和 H3K56ac 的蛋白表达。
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