产品
编 号：F753987
分子式：C30H28ClN3O3
分子量：514.01
分子式：C30H28ClN3O3
分子量：514.01
产品类型
规格
价格
是否有货
结构图
CAS No: 2592638-14-5
产品详情
生物活性：
CBP/p300-IN-19 hydrochloride is a potent and selective p300/CBP HAT inhibitor with IC50s of 1.4, 2.2, >100, >100 μM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 hydrochloride shows antitumor activity.
体外研究：
CBP/p300-IN-19 hydrochloride (compound 29) shows antiproliferative activity with EC50s of 5.3, 8.5, 6.2, 4.4, 1.2, 4.3, 3.6, 8.7, 6.4 μM for MCF-7, MDA-MB231, LNCaP, PC-3, PANC-1, MDA-PANC-28, Molm-13, MV4;11, RPMI-8226 cells, respectively.CBP/p300-IN-19 hydrochloride (0, 5, 10 μM; 12 h) dose-dependenly inhibits the acetylation of H3K18, H3K9 and K27.
CBP/p300-IN-19 hydrochloride is a potent and selective p300/CBP HAT inhibitor with IC50s of 1.4, 2.2, >100, >100 μM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 hydrochloride shows antitumor activity.
体外研究：
CBP/p300-IN-19 hydrochloride (compound 29) shows antiproliferative activity with EC50s of 5.3, 8.5, 6.2, 4.4, 1.2, 4.3, 3.6, 8.7, 6.4 μM for MCF-7, MDA-MB231, LNCaP, PC-3, PANC-1, MDA-PANC-28, Molm-13, MV4;11, RPMI-8226 cells, respectively.CBP/p300-IN-19 hydrochloride (0, 5, 10 μM; 12 h) dose-dependenly inhibits the acetylation of H3K18, H3K9 and K27.
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