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编 号：F753963
分子式：C21H10Cl2F3NO5S
分子量：516.27
分子式：C21H10Cl2F3NO5S
分子量：516.27
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CAS No: 2589639-87-0
产品详情
生物活性：
Antibacterial agent 89 is a potent antibacterial agent. Antibacterial agent 89 shows anti-clostridial activity. Antibacterial agent 89 inhibits the release of cytotoxins and the β’CH-σ interaction. Antibacterial agent 89 disrupts the process of bacterial transcription.
体外研究：
Antibacterial agent 89 (compound 8 e) shows antimicrobial activity for SPNE (Streptococcus pneumoniae (S. pneumoniae)) ATCC 49619, Streptococcus aureus (S. aureus) ATCC 25923, S. aureus ATCC 29213 with MIC of 2, 4, 4 μg/mL, respectively.Antibacterial agent 89 (48 h) shows anti-clostridial activity against clinically important Gram-positive pathogens with MIC of 0-8 μg/mL.Antibacterial agent 89 (48 h) inhibits the release of cytotoxins Toxin A (TcdA) and Toxin B (TcdB) in a dose-dependent manner in C. difficile ATCC 9689, ribotype 002, ribotype 027.Antibacterial agent 89 inhibits the β’CH-σ interaction with an IC50 of 2.12 μM.Antibacterial agent 89 (1, 2, 4 μg/mL; B. subtilis) alters the localization of bacterial transcription complexes.Antibacterial agent 89 (0.5, 0.25 μg/mL) reduces the expression of DNA, RNA, protein levels in S. aureus ATCC 29213 cells.
Antibacterial agent 89 is a potent antibacterial agent. Antibacterial agent 89 shows anti-clostridial activity. Antibacterial agent 89 inhibits the release of cytotoxins and the β’CH-σ interaction. Antibacterial agent 89 disrupts the process of bacterial transcription.
体外研究：
Antibacterial agent 89 (compound 8 e) shows antimicrobial activity for SPNE (Streptococcus pneumoniae (S. pneumoniae)) ATCC 49619, Streptococcus aureus (S. aureus) ATCC 25923, S. aureus ATCC 29213 with MIC of 2, 4, 4 μg/mL, respectively.Antibacterial agent 89 (48 h) shows anti-clostridial activity against clinically important Gram-positive pathogens with MIC of 0-8 μg/mL.Antibacterial agent 89 (48 h) inhibits the release of cytotoxins Toxin A (TcdA) and Toxin B (TcdB) in a dose-dependent manner in C. difficile ATCC 9689, ribotype 002, ribotype 027.Antibacterial agent 89 inhibits the β’CH-σ interaction with an IC50 of 2.12 μM.Antibacterial agent 89 (1, 2, 4 μg/mL; B. subtilis) alters the localization of bacterial transcription complexes.Antibacterial agent 89 (0.5, 0.25 μg/mL) reduces the expression of DNA, RNA, protein levels in S. aureus ATCC 29213 cells.
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