产品
编 号：F753949
分子式：C19H21BrClNO
分子量：394.73
分子式：C19H21BrClNO
分子量：394.73
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 2587360-22-1
产品详情
生物活性：
Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrobromide can be used for the research of schizophrenia and obesity.
体内研究：
Ecopipam hydrobromide (10，mg/kg，口服) 拮抗大鼠中 Apomorphine 诱导的刻板印象。Ecopipam hydrobromide (5 和 10 μM，灌注，1 μL/分钟) 可逆地和剂量依赖性地减少大鼠纹状体中乙酰胆碱的释放。Animal Model:Male young adult Long-Evans rats were injected with Nicotine
Dosage:0.003, 0.01, 0.03, 0.1, 0.3 mg/kg
Administration:A single s.c. 20 min before Nicotine (0.1 mg/kg)
Result:Dose-dependently reduced pressing on both active and inactive levers.
体外研究：
Ecopipam (2 μM) hydrobromide 完全消除多巴胺 (10 μM) 在孤立的皮质海马结构中的促惊厥作用。
Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrobromide can be used for the research of schizophrenia and obesity.
体内研究：
Ecopipam hydrobromide (10，mg/kg，口服) 拮抗大鼠中 Apomorphine 诱导的刻板印象。Ecopipam hydrobromide (5 和 10 μM，灌注，1 μL/分钟) 可逆地和剂量依赖性地减少大鼠纹状体中乙酰胆碱的释放。Animal Model:Male young adult Long-Evans rats were injected with Nicotine
Dosage:0.003, 0.01, 0.03, 0.1, 0.3 mg/kg
Administration:A single s.c. 20 min before Nicotine (0.1 mg/kg)
Result:Dose-dependently reduced pressing on both active and inactive levers.
体外研究：
Ecopipam (2 μM) hydrobromide 完全消除多巴胺 (10 μM) 在孤立的皮质海马结构中的促惊厥作用。
产品资料
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